Department of Psychiatry , Helsinki University Central Hospital, Jorvi Hospital, Espoo, Finland.
J Ment Health. 2013 Aug;22(4):317-24. doi: 10.3109/09638237.2012.734654. Epub 2013 Jan 16.
Depression and psychosis are severe diseases with onset in adolescence.
The aim of this study was to investigate the association between an at-risk status of psychosis and depression symptoms in adolescents.
The data were collected by an early intervention team in Finland. The PROD screen was used to assess the risk of psychosis, and Beck Depression Inventory-II was used as a measurement to assess the level of depression symptoms. Of 203 help-seeking respondents, 66 were classified as at-risk for psychosis, and 137 respondents were other help-seekers. The mean age of the subjects was 15.3 years.
Subjects at-risk had significantly poorer scores in total scores for depression (p < 0.001), and in an item-by-item analysis, the subjects at-risk had poorer scores for sadness (p < 0.001), past failure (p = 0.001), suicidal thoughts (p < 0.001), crying (p = 0.002), agitation (p = 0.001), loss of energy (p = 0.002) and concentration difficulty (p < 0.001). In a logistic regression analysis of items that differed by risk status for psychosis, item of concentration difficulty (p = 0.038) explained the at-risk status after adjustment for sex.
The present results suggest that subjects that are at-risk for psychosis have more depression symptoms than other help-seekers. This should be considered in the psychiatric care of adolescents.
抑郁和精神病是在青少年时期发病的严重疾病。
本研究旨在探讨青少年精神病风险状况与抑郁症状之间的关系。
该数据由芬兰的一个早期干预小组收集。使用 PROD 筛查来评估精神病风险，使用贝克抑郁量表 II 作为评估抑郁症状水平的测量工具。在 203 名寻求帮助的受访者中，有 66 人被归类为精神病风险者，有 137 人是其他寻求帮助者。受试者的平均年龄为 15.3 岁。
有风险的受试者在抑郁总分上的得分明显较差（p < 0.001），在逐项分析中，有风险的受试者在悲伤（p < 0.001）、过去的失败（p = 0.001）、自杀念头（p < 0.001）、哭泣（p = 0.002）、激动（p = 0.001）、精力丧失（p = 0.002）和注意力困难（p < 0.001）方面的得分较差。在对精神病风险状况不同的项目进行逻辑回归分析时，注意力困难项目（p = 0.038）在调整性别后解释了风险状况。
目前的结果表明，有精神病风险的受试者比其他寻求帮助者有更多的抑郁症状。这在青少年的精神保健中应加以考虑。
