Wip1 调控：谁控制着重置按钮？
Wip1 regulation: who controls a reset button?
机构信息
Unidad de Investigación, Hospital Universitario de Canarias, Instituto de Tecnologías Biomédicas, La Laguna, Tenerife, Spain.
出版信息
Cell Cycle. 2013 Feb 1;12(3):390. doi: 10.4161/cc.23554. Epub 2013 Jan 16.
Abstract
Comment on: Macurek L, et al. Cell Cycle 2013; 12:251-62.
摘要
评论
Macurek L 等人。细胞周期 2013；12:251-62.
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Wip1 regulation: who controls a reset button?Wip1 调控：谁控制着重置按钮？
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本文引用的文献
1
Downregulation of Wip1 phosphatase modulates the cellular threshold of DNA damage signaling in mitosis.Wip1 磷酸酶的下调调节有丝分裂中 DNA 损伤信号的细胞阈值。
Cell Cycle. 2013 Jan 15;12(2):251-62. doi: 10.4161/cc.23057. Epub 2012 Jan 15.
2
Give me a break, but not in mitosis: the mitotic DNA damage response marks DNA double-strand breaks with early signaling events.饶了我吧，但不是在有丝分裂期间：有丝分裂 DNA 损伤反应通过早期信号事件标记 DNA 双链断裂。
Cell Cycle. 2011 Apr 15;10(8):1215-21. doi: 10.4161/cc.10.8.15334.
3
53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress.53BP1 核体围绕在复制压力下有丝分裂传递染色体产生的 DNA 损伤处形成。
Nat Cell Biol. 2011 Mar;13(3):243-53. doi: 10.1038/ncb2201. Epub 2011 Feb 13.
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Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway.致癌性Wip1磷酸酶在DNA损伤信号通路中受到miR-16的抑制。
Cancer Res. 2010 Sep 15;70(18):7176-86. doi: 10.1158/0008-5472.CAN-10-0697. Epub 2010 Jul 28.
5
Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition.Wip1 磷酸酶与染色质相关，去磷酸化 γH2AX 以促进检查点抑制。
Oncogene. 2010 Apr 15;29(15):2281-91. doi: 10.1038/onc.2009.501. Epub 2010 Jan 25.
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WIP1 phosphatase at the crossroads of cancer and aging.WIP1 磷酸酶——癌症与衰老的交汇点。
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