Department of Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine, 211, Eonju-ro, Gangnam-Gu, Seoul 135-720, South Korea.
Breast Cancer Res Treat. 2013 Feb;138(1):119-26. doi: 10.1007/s10549-013-2407-3. Epub 2013 Jan 17.
To compare the mean elasticity value, as measured by shear-wave elastography (SWE), with immunohistochemical profile of invasive breast cancer. This was an institutional review board-approved retrospective study, with a waiver of informed consent. A total of 166 invasive breast cancers in 152 women undergoing preoperative SWE and surgery were included. Quantitative mean elasticity values in kPa were measured for each lesion by using SWE. Medical records were reviewed to determine palpability, invasive size, lymphovascular invasion, histologic grade, and axillary lymph node status. Based on the immunohistochemical profiles, tumor subtypes were categorized as triple-negative (TN), luminal A and B, or human epidermal growth factor receptor 2-enriched cancer. The mean elasticity value was correlated with clinicopathological features using univariate regression models and multivariate linear regression analysis. Palpability (P < 0.0001), larger size (P = 0.013), lymphovascular invasion (P < 0.0001), higher histologic grade (P < 0.0001), and lymph node involvement (P = 0.018) were significantly associated with the mean elasticity value. For the immunohistochemical profiles and tumor subtypes, the estrogen receptor (P = 0.015), progesterone receptor (P = 0.002), Ki-67 (P = 0.009), and the TN (P = 0.009) tumor subtype were correlated with the mean elasticity value. Multivariate logistic regression analysis showed that the following variables were significantly associated with the mean elasticity value: palpable abnormality, histologic grade, and lymphovascular invasion. No immunohistochemical profile of the cancers was independently correlated with the mean elasticity value. For invasive breast cancers, clinicopathological features of poor prognosis showed higher mean elasticity values than those of good prognosis. However, the immunohistochemical profile showed no independent association with the mean elasticity value.
比较剪切波弹性成像（SWE）测量的平均弹性值与浸润性乳腺癌的免疫组织化学特征。这是一项机构审查委员会批准的回顾性研究，豁免了知情同意。共纳入 152 例行术前 SWE 检查和手术的女性的 166 例浸润性乳腺癌。通过 SWE 测量每个病变的定量平均弹性值（kPa）。回顾病历以确定可触性、浸润性大小、脉管侵犯、组织学分级和腋窝淋巴结状态。根据免疫组织化学特征，将肿瘤亚型分为三阴性（TN）、 luminal A 和 B 或人表皮生长因子受体 2 富集型癌症。使用单变量回归模型和多元线性回归分析，将平均弹性值与临床病理特征相关联。可触性（P<0.0001）、较大的大小（P=0.013）、脉管侵犯（P<0.0001）、较高的组织学分级（P<0.0001）和淋巴结受累（P=0.018）与平均弹性值显著相关。对于免疫组织化学特征和肿瘤亚型，雌激素受体（P=0.015）、孕激素受体（P=0.002）、Ki-67（P=0.009）和 TN（P=0.009）肿瘤亚型与平均弹性值相关。多变量逻辑回归分析显示，以下变量与平均弹性值显著相关：可触性异常、组织学分级和脉管侵犯。癌症的免疫组织化学特征与平均弹性值无独立相关性。对于浸润性乳腺癌，预后不良的临床病理特征显示出比预后良好的更高的平均弹性值。然而，免疫组织化学特征与平均弹性值无独立关联。
