Digestive Endoscopy Unit, University Hospital, Messina 98100, Italy.
Eur J Gastroenterol Hepatol. 2013 Apr;25(4):503-6. doi: 10.1097/MEG.0b013e32835c8df2.
We report a case of an 84-year-old woman with a history of resected cutaneous melanoma who presented with asthenia, weight loss, and severe anemia. An esophagogastroduodenoscopy showed five black-pigmented submucosal tumors with large ulcerations in the antrum of the stomach and in the duodenum, suspected metastases from melanoma. Histopathological examination indicated the presence of melanin-containing tumor cells and confirmed an ulcerated pigmented melanoma. To examine the entire gastrointestinal tract, capsule endoscopy was performed and it showed a simultaneous massive involvement of the jejunum and ileum, with more than 40 lesions. This case highlights the importance of a complete endoscopic gastrointestinal examination in patients with melanoma metastatic to the bowel and suggests that capsule endoscopy is an easy, noninvasive, and effective diagnostic procedure to investigate small-bowel involvement.
我们报告了一例 84 岁女性，既往有切除的皮肤黑色素瘤病史，现出现乏力、体重减轻和严重贫血。食管胃十二指肠镜检查显示胃窦和十二指肠有五个黑色素瘤样的黏膜下肿瘤，伴有大溃疡，考虑为黑色素瘤转移。组织病理学检查提示存在含黑色素的肿瘤细胞，证实为溃疡性色素性黑色素瘤。为检查整个胃肠道，进行了胶囊内镜检查，显示空肠和回肠同时有大量受累，有超过 40 处病变。本病例强调了对肠道转移性黑色素瘤患者进行全面内镜胃肠道检查的重要性，并提示胶囊内镜是一种简单、无创和有效的诊断方法，可用于检查小肠受累情况。
