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[胃肠道转移性黑色素瘤的手术切除]

[Surgical resection for gastrointestinal metastatic melanoma].

作者信息

Dequanter D, Sales F, Legendre H, Lothaire P, Pector J-C

机构信息

Département de chirurgie, institut Jules Bordet, rue Héger-Bordet, 1, 1000 Bruxelles, Belgique.

出版信息

Ann Chir. 2004 Jun;129(5):278-81. doi: 10.1016/j.anchir.2004.01.016.

Abstract

AIM

Metastases of melanoma are frequent. On the gastro-intestinal tract, commonest localizations are small bowel, stomach and colon. Surgical treatment of digestive metastases from melanoma is not well known and its value is still debated.

PATIENTS AND METHODS

Medical records of 10 patients (six female and four male) operated for metastatic melanoma to gastro-intestinal tract were reviewed to determine results of surgery.

RESULTS

Gastro-intestinal metastases were symptomatic in eight patients (abdominal pain in three, bowel obstruction in three, abdominal mass and obstructive jaundice in one each). Two patients had anemia. Diagnosis has been suggested by imaging in seven patients and endoscopy in three. All patients were operated on by laparotomy for resection of metastases located on small bowel in four patients, gallbladder in two, stomach in two and colon in two. Complete resection suppressed symptoms in nine cases. In one patient, resection was incomplete but provided satisfying symptomatic relief. One patient died at day 3; in other patients, median survival was 18 months (range: 3-120).

CONCLUSION

In a patient with previous history of melanoma, digestive symptoms indicate morphological explorations due to suspicion of metastases to gastro-intestinal tract. Surgical treatment of these metastases is usually palliative but, in some cases, allows long-term survival.

摘要

目的

黑色素瘤转移常见。在胃肠道,最常见的部位是小肠、胃和结肠。黑色素瘤消化转移灶的外科治疗并不为人熟知,其价值仍存在争议。

患者与方法

回顾了10例(6例女性,4例男性)因胃肠道转移性黑色素瘤接受手术治疗的患者病历,以确定手术结果。

结果

8例患者的胃肠道转移灶出现症状(3例腹痛,3例肠梗阻,1例腹部肿块,1例梗阻性黄疸)。2例患者有贫血。7例患者通过影像学检查、3例患者通过内镜检查提示诊断。所有患者均接受剖腹手术,4例患者切除小肠转移灶,2例切除胆囊转移灶,2例切除胃转移灶,2例切除结肠转移灶。9例患者症状因完全切除而缓解。1例患者切除不完全,但症状缓解满意。1例患者在术后第3天死亡;其他患者的中位生存期为18个月(范围:3 - 120个月)。

结论

对于有黑色素瘤病史的患者,消化症状提示怀疑胃肠道转移时需进行形态学检查。这些转移灶的外科治疗通常是姑息性的,但在某些情况下可实现长期生存。

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