墨西哥裔美国9岁儿童围产期因素与脂联素和瘦素之间的关联。
Associations between perinatal factors and adiponectin and leptin in 9-year-old Mexican-American children.
作者信息
Volberg Vitaly, Harley Kim G, Aguilar Raul S, Rosas Lisa G, Huen Karen, Yousefi Paul, Davé Veronica, Phan Nguyet, Lustig Robert H, Eskenazi Brenda, Holland Nina
机构信息
Center for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley, Berkeley, CA, USA.
出版信息
Pediatr Obes. 2013 Dec;8(6):454-63. doi: 10.1111/j.2047-6310.2012.00127.x. Epub 2013 Jan 16.
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT
Mexican-American children are at particularly high risk of obesity. Features of the perinatal environment, including maternal nutrition, anthropometry, glucose tolerance and growth rate during infancy are implicated in programming of obesity in the offspring.
WHAT THIS STUDY ADDS
Greater rate of weight or length gain in the first 6 months of life is associated with lower 9-year child adiponectin levels, adjusting for 9-year child BMI. Nine-year-old child adipokine levels are strongly related to those of their mothers'.
OBJECTIVES
To (i) determine whether perinatal factors (including maternal anthropometry and nutrition and early life growth measures) are associated with adiponectin and leptin levels in 9-year-old children, and (ii) assess relationships between adiponectin, leptin and concurrent lipid profile in these children.
METHODS
We measured plasma adiponectin and leptin for 146 mothers-9-year-old child pairs from the ongoing longitudinal birth cohort followed by the Center for the Health Assessment of Mothers and Children of Salinas. Data on perinatal factors, including sociodemographics, maternal anthropometry and nutrition, and early life child growth were collected during pregnancy, birth and 6-month visits.
RESULTS
Greater rate of weight and length gain during the first 6 months of life were associated with lower adiponectin in 9-year-olds (β = -2.0, P = 0.04; β = -8.2, P = 0.02, respectively) adjusting for child body mass index (BMI). We found no associations between child adipokine levels and either maternal calorie, protein, total fat, saturated fat, fibre, sugar-sweetened beverage consumption during pregnancy or children's concurrent sugar-sweetened beverage and fast food intake. Lipid profile in 9-year-old children closely reflected adiponectin but not leptin levels after adjustment for child BMI. Additionally, we report that child adipokine levels were closely related to their mothers' levels at the 9-year visit.
CONCLUSION
Overall, our results support the hypothesis that early life factors may contribute to altered adipokine levels in children.
关于该主题的已知信息
墨西哥裔美国儿童肥胖风险特别高。围产期环境特征，包括母亲营养、人体测量学指标、糖耐量以及婴儿期生长速率，都与后代肥胖的编程有关。
本研究的新增内容
在根据9岁儿童体重指数（BMI）进行调整后，生命最初6个月内体重或身长增加速率更快与9岁儿童脂联素水平较低相关。9岁儿童的脂肪因子水平与其母亲的脂肪因子水平密切相关。
目的
（i）确定围产期因素（包括母亲人体测量学指标和营养状况以及生命早期生长指标）是否与9岁儿童的脂联素和瘦素水平相关，以及（ii）评估这些儿童脂联素、瘦素与同期血脂谱之间的关系。
方法
我们对来自萨利纳斯母婴健康评估中心正在进行的纵向出生队列研究中的146对母亲及其9岁孩子进行了血浆脂联素和瘦素检测。在孕期、分娩时及6个月随访时收集了围产期因素数据，包括社会人口统计学信息、母亲人体测量学指标和营养状况以及生命早期儿童生长情况。
结果
在根据儿童体重指数（BMI）进行调整后，生命最初6个月内体重和身长增加速率更快与9岁儿童脂联素水平较低相关（β分别为 -2.0，P = 0.04；β为 -8.2，P = 0.02）。我们发现儿童脂肪因子水平与母亲孕期卡路里、蛋白质、总脂肪量、饱和脂肪量、纤维、含糖饮料摄入量，或儿童同期含糖饮料和快餐摄入量之间均无关联。在根据儿童BMI进行调整后，9岁儿童的血脂谱密切反映脂联素水平，但不反映瘦素水平。此外，我们报告称，在9岁随访时，儿童脂肪因子水平与其母亲的水平密切相关。
结论
总体而言，我们的结果支持以下假设，即生命早期因素可能导致儿童脂肪因子水平改变。
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