Grubbe R E, Hopp R, Dave N K, Brennan B, Bewtra A, Townley R
Allergic Disease Center, Creighton University, Omaha, NE 68178.
J Allergy Clin Immunol. 1990 May;85(5):881-4. doi: 10.1016/0091-6749(90)90072-c.
Inhaled furosemide has been recently demonstrated to inhibit the bronchoconstrictive effects of exercise, ultrasonically nebulized distilled water, and antigen challenge. The presumed mechanism of action of these challenges is through mast cell degranulation. We report on the effect of inhaled furosemide on cold-air hyperventilation challenge (CAHC) and methacholine challenge. We studied 10 subjects with mild to moderate asthma in a double-blind, placebo-controlled, crossover study. Inhaled furosemide did not affect FEV1 in the hour after inhalation, and there was no significant difference between placebo or furosemide on the dose of methacholine causing a 20% fall in FEV1. Our results demonstrated inhaled furosemide significantly attenuated the bronchoconstrictive effect at 6 and 9 minutes after CAHC (p less than 0.05 and 0.029, respectively) when furosemide was compared to placebo and approached significance at 12 and 15 minutes after CAHC (p = 0.052 and 0.56, respectively). Inhaled furosemide attenuates CAHC but does not effect methacholine-induced bronchoconstriction.
近期研究表明，吸入速尿可抑制运动、超声雾化蒸馏水及抗原激发引起的支气管收缩效应。这些激发作用的推测作用机制是通过肥大细胞脱颗粒。我们报告了吸入速尿对冷空气过度通气激发试验（CAHC）和乙酰甲胆碱激发试验的影响。我们在一项双盲、安慰剂对照、交叉研究中对10名轻度至中度哮喘患者进行了研究。吸入速尿在吸入后1小时内对第一秒用力呼气量（FEV1）无影响，且在导致FEV1下降20%的乙酰甲胆碱剂量方面，安慰剂与速尿之间无显著差异。我们的结果表明，与安慰剂相比，吸入速尿在CAHC后6分钟和9分钟时显著减轻了支气管收缩效应（p分别小于0.05和0.029），在CAHC后12分钟和15分钟时接近显著水平（p分别为0.052和0.56）。吸入速尿可减轻CAHC，但对乙酰甲胆碱诱导的支气管收缩无影响。
