β-肾上腺素能使平滑肌舒张的机制。
Mechanism of beta-adrenergic relaxation of smooth muscle.
作者信息
Scheid C R, Honeyman T W, Fay F S
出版信息
Nature. 1979 Jan 4;277(5691):32-6. doi: 10.1038/277032a0.
DOI:10.1038/277032a0
PMID:233257
Abstract
The mechanism of beta-adrenergic relaxation was investigated in isolated smooth muscle cells. Beta-adrenergic agents stimulate cyclic AMP-dependent phosphorylation, enhance Na+/K+ transport and induce relaxation. The stimulation of Na+/K+ transport is obligatory for relaxation, and we suggest that this stimulation induces relaxation through enhanced Na+/Ca2+ exchange.
摘要
在分离的平滑肌细胞中研究了β-肾上腺素能舒张的机制。β-肾上腺素能药物刺激环磷酸腺苷（cAMP）依赖性磷酸化，增强钠/钾转运并诱导舒张。钠/钾转运的刺激对于舒张是必不可少的，我们认为这种刺激通过增强钠/钙交换诱导舒张。
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