自身免疫在原发性胆汁性肝硬化中的作用。
Role of autoimmunity in primary biliary cirrhosis.
机构信息
Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing 100032, China.
出版信息
World J Gastroenterol. 2012 Dec 28;18(48):7141-8. doi: 10.3748/wjg.v18.i48.7141.
Abstract
Primary biliary cirrhosis (PBC) is an autoimmune liver disease characterized by the presence of serum autoantibodies and chronic nonsuppurative destructive cholangitis. The pathogenesis of PBC involves environmental factors, genetic predisposition and loss of immune tolerance. In recent years, it has become univocally accepted that an inappropriately activated immune response is one of the most important factors in PBC. In this study, the role of autoimmunity in PBC is summarized and a feasible research orientation is recommended.
摘要
原发性胆汁性肝硬化（PBC）是一种自身免疫性肝病，其特征是血清自身抗体和慢性非化脓性破坏性胆管炎的存在。PBC 的发病机制涉及环境因素、遗传易感性和免疫耐受丧失。近年来，人们普遍认为，不适当的免疫反应是 PBC 的最重要因素之一。在这项研究中，总结了自身免疫在 PBC 中的作用，并提出了一个可行的研究方向。
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