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A platelet acquired storage pool disorder associated with tamoxifen therapy.一种与他莫昔芬治疗相关的血小板获得性贮存池病。
Case Rep Hematol. 2012;2012:948351. doi: 10.1155/2012/948351. Epub 2012 Dec 26.
2
Anti-thrombotic effects of selective estrogen receptor modulator tamoxifen.选择性雌激素受体调节剂他莫昔芬的抗血栓作用。
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Patients with a prolonged bleeding time and normal aggregation tests may have storage pool deficiency: studies on one hundred six patients.出血时间延长而聚集试验正常的患者可能存在储存池缺陷：对106例患者的研究。
Blood. 1987 Sep;70(3):620-3.
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Clinical Trial Evaluating the Risk of Thromboembolic Events During Dental Extractions.评估拔牙期间血栓栓塞事件风险的临床试验
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Antithrombin III level, fibrinogen level, and platelet count changes with adjuvant tamoxifen therapy.抗凝血酶III水平、纤维蛋白原水平及血小板计数随他莫昔芬辅助治疗的变化。
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An Antiestrogenic Activity Score for tamoxifen and its metabolites is associated with breast cancer outcome.他莫昔芬及其代谢产物的抗雌激素活性评分与乳腺癌预后相关。
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Tamoxifen and the isomers of 4-hydroxytamoxifen in tamoxifen-resistant tumors from breast cancer patients.
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Metastatic invasive lobular carcinoma of the breast to the endometrium presenting with abnormal uterine bleeding; Case report.以异常子宫出血为表现的乳腺小叶浸润癌转移至子宫内膜；病例报告。
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本文引用的文献

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Tamoxifen promotes superoxide production in platelets by activation of PI3-kinase and NADPH oxidase pathways.他莫昔芬通过激活 PI3-激酶和 NADPH 氧化酶途径促进血小板中超氧化物的产生。
Thromb Res. 2012 Jan;129(1):36-42. doi: 10.1016/j.thromres.2011.08.010. Epub 2011 Aug 27.
2
Anti-thrombotic effects of selective estrogen receptor modulator tamoxifen.选择性雌激素受体调节剂他莫昔芬的抗血栓作用。
Thromb Haemost. 2011 Oct;106(4):624-35. doi: 10.1160/TH11-03-0178. Epub 2011 Aug 25.
3
A novel role for tamoxifen in the inhibition of human platelets.三苯氧胺在抑制人血小板中的新作用。
Transl Res. 2011 Feb;157(2):81-91. doi: 10.1016/j.trsl.2010.10.004. Epub 2010 Nov 30.
4
Role of raloxifene on platelet metabolism and plasma lipids.雷洛昔芬对血小板代谢和血脂的作用。
Eur J Clin Invest. 2008 Feb;38(2):117-25. doi: 10.1111/j.1365-2362.2007.01905.x.
5
Tamoxifen stimulates calcium entry into human platelets.他莫昔芬刺激钙离子进入人血小板。
J Cardiovasc Pharmacol. 2007 Oct;50(4):380-90. doi: 10.1097/FJC.0b013e31811ec748.
6
A flow cytometric assay for the study of dense granule storage and release in human platelets.
Platelets. 1999;10(2-3):153-8. doi: 10.1080/09537109976239.
7
Platelet aggregation testing in platelet-rich plasma: description of procedures with the aim to develop standards in the field.富血小板血浆中的血小板聚集试验：旨在制定该领域标准的操作流程描述。
Am J Clin Pathol. 2005 Feb;123(2):172-83. doi: 10.1309/y9ec-63rw-3xg1-v313.
8
The effects of tamoxifen and its metabolites on platelet function and release of reactive oxygen intermediates.他莫昔芬及其代谢产物对血小板功能和活性氧中间体释放的影响。
J Pharmacol Exp Ther. 2005 Mar;312(3):1144-50. doi: 10.1124/jpet.104.076315. Epub 2004 Oct 27.
9
Activation of caspase-3 and c-Jun NH2-terminal kinase-1 signaling pathways in tamoxifen-induced apoptosis of human breast cancer cells.在他莫昔芬诱导的人乳腺癌细胞凋亡中半胱天冬酶-3和c-Jun氨基末端激酶-1信号通路的激活
Cancer Res. 2000 Nov 1;60(21):5995-6000.
10
The effect of tamoxifen and hormone replacement therapy on serum cholesterol, bone mineral density and coagulation factors in healthy postmenopausal women participating in a randomised, controlled tamoxifen prevention study.他莫昔芬和激素替代疗法对参与一项随机对照他莫昔芬预防研究的健康绝经后妇女血清胆固醇、骨密度和凝血因子的影响。
Ann Oncol. 1996 Sep;7(7):671-5. doi: 10.1093/oxfordjournals.annonc.a010715.

一种与他莫昔芬治疗相关的血小板获得性贮存池病。

A platelet acquired storage pool disorder associated with tamoxifen therapy.

作者信息

Nayak Lalitha, Schmaier Alvin H

机构信息

Seidman Cancer Center, University Hospitals Case Medical Center and Division of Hematology and Oncology, Department of Medicine, Case Western Reserve University, 10900 Euclid Avenue, WRB2-130, Cleveland, OH 44106-7284, USA.

出版信息

Case Rep Hematol. 2012;2012:948351. doi: 10.1155/2012/948351. Epub 2012 Dec 26.

DOI:10.1155/2012/948351
PMID:23326738
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3541551/
Abstract

The antiestrogenic drug tamoxifen, used in patients with breast cancer, is associated with an increase in arterial and venous thrombotic events, the mechanism of which is not clearly understood. We report a case of a lady who presented with new bruising and prolonged bleeding following a tooth extraction 4-6 weeks after starting tamoxifen. Investigations were consistent with an acquired platelet storage pool disorder. Repeat platelet function analysis was normal, performed 3 months after discontinuation of tamoxifen. We present a previously clinically unreported effect of tamoxifen on platelet function.

摘要

用于乳腺癌患者的抗雌激素药物他莫昔芬与动脉和静脉血栓形成事件的增加有关，其机制尚不清楚。我们报告了一例女性患者，在开始服用他莫昔芬4 - 6周后拔牙，出现了新的瘀伤和出血时间延长的情况。检查结果符合获得性血小板贮存池病。在停用他莫昔芬3个月后进行的重复血小板功能分析结果正常。我们展示了他莫昔芬对血小板功能的一种此前未被临床报道的作用。