Second Department of Internal Medicine, Endocrinology, Diabetes and Metabolism, Hematology and Rheumatology, University of the Ryukyus Graduate School of Medicine, Okinawa 903-0215, Japan.
Cardiol Res Pract. 2012;2012:754181. doi: 10.1155/2012/754181. Epub 2012 Dec 26.
We investigated the effects of purified eicosapentaenoic acid (EPA) on vascular endothelial function and free fatty acid composition in Japanese hyperlipidemic subjects. In subjects with hyperlipidemia (total cholesterol ≥220 mg/dL and/or triglycerides ≥150 mg/dL), lipid profile and forearm blood flow (FBF) during reactive hyperemia were determined before and 3 months after supplementation with 1800 mg/day EPA. Peak FBF during reactive hyperemia was lower in the hyperlipidemic group than the normolipidemic group. EPA supplementation did not change serum levels of total, HDL, or LDL cholesterol, apolipoproteins, remnant-like particle (RLP) cholesterol, RLP triglycerides, or malondialdehyde-modified LDL cholesterol. EPA supplementation did not change total free fatty acid levels in serum, but changed the fatty acid composition, with increased EPA and decreased linoleic acid, γ-linolenic acid, and dihomo-γ-linolenic acid. EPA supplementation recovered peak FBF after 3 months. Peak FBF recovery was correlated positively with EPA and EPA/arachidonic acid levels and correlated inversely with dihomo-γ-linolenic acid. EPA supplementation restores endothelium-dependent vasodilatation in hyperlipidemic patients despite having no effect on serum cholesterol and triglyceride patterns. These results suggest that EPA supplementation may improve vascular function at least partly via changes in fatty acid composition.
我们研究了纯化二十碳五烯酸 (EPA) 对日本高血脂患者血管内皮功能和游离脂肪酸组成的影响。在高血脂患者（总胆固醇≥220mg/dL 和/或甘油三酯≥150mg/dL）中，在补充 1800mg/天 EPA 前后测定血脂谱和反应性充血期间的前臂血流 (FBF)。反应性充血期间的最大 FBF 在高脂血症组中低于正常血脂组。EPA 补充剂并未改变血清总胆固醇、HDL 或 LDL 胆固醇、载脂蛋白、残粒样颗粒 (RLP) 胆固醇、RLP 甘油三酯或丙二醛修饰的 LDL 胆固醇水平。EPA 补充剂并未改变血清中总游离脂肪酸水平，但改变了脂肪酸组成，增加了 EPA，减少了亚油酸、γ-亚麻酸和二同型-γ-亚麻酸。EPA 补充剂在 3 个月后恢复了最大 FBF。最大 FBF 恢复与 EPA 和 EPA/花生四烯酸水平呈正相关，与二同型-γ-亚麻酸呈负相关。尽管 EPA 补充剂对血清胆固醇和甘油三酯模式没有影响，但它可以恢复高血脂患者的内皮依赖性血管舒张功能。这些结果表明，EPA 补充剂可能通过改变脂肪酸组成至少部分地改善血管功能。
