Mohammadizadeh Fereshteh, Ranaee Mohammad, Zavareh Mohsen Hani Tabaei, Faghihi Mehri, Saremi Mahdieh, Eftekhari Mehdi
Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Ayatollah Rouhani Hospital, Isfahan, Iran.
Adv Biomed Res. 2012;1:55. doi: 10.4103/2277-9175.100172. Epub 2012 Aug 28.
Invasive breast carcinoma is one of the most common cancers of women. Parameters such as lymph node status, tumor grade, and the status of hormone receptors are among the main prognostic determinants of this cancer. Immunohistochemical detection of prostate-specific antigen (PSA) is widely used to identify metastatic prostatic adenocarcinoma. However, its immunoreactivity has been found in some non-prostatic tissues. This study was conducted to assess PSA expression in invasive breast carcinoma and its relationship with routine clinicopathologic parameters.
100 formalin-fixed and paraffin-embedded invasive breast carcinoma tissue specimens from the pathology archive of Alzahra hospital (Isfahan, Iran) were studied for the expression of estrogen receptor (ER), progesterone receptor (PR), HER2/neu, and PSA by immunohistochemistry. Stained sections were classified according to the intensity of staining and the percentage of cells showing PSA staining. The relationship between PSA expression and other markers, age, lymph node status, tumor subtype, and tumor grade was then studied.
No association was found between PSA expression on one hand and PR, Her2/neu, age, lymph node status, tumor grade, and tumor subtype on the other. PSA score was reversely correlated with ER expression (P = 0.015).
Despite the reverse relationship between PSA expression and the immunoreactivity of ER, PSA expression was not correlated with other prognostic factors. Therefore, the detection of PSA by immunohistochemistry does not seem to be a significant prognostic parameter in patients with invasive breast carcinoma.
浸润性乳腺癌是女性最常见的癌症之一。淋巴结状态、肿瘤分级和激素受体状态等参数是该癌症主要的预后决定因素。免疫组化检测前列腺特异性抗原（PSA）广泛用于识别转移性前列腺腺癌。然而，在一些非前列腺组织中也发现了其免疫反应性。本研究旨在评估浸润性乳腺癌中PSA的表达及其与常规临床病理参数的关系。
对来自阿尔扎赫拉医院（伊朗伊斯法罕）病理档案的100例福尔马林固定石蜡包埋的浸润性乳腺癌组织标本进行免疫组化研究，以检测雌激素受体（ER）、孕激素受体（PR）、HER2/neu和PSA的表达。根据染色强度和显示PSA染色的细胞百分比对染色切片进行分类。然后研究PSA表达与其他标志物、年龄、淋巴结状态、肿瘤亚型和肿瘤分级之间 的关系。
一方面，PSA表达与PR、Her2/neu、年龄、淋巴结状态、肿瘤分级和肿瘤亚型之间未发现相关性。PSA评分与ER表达呈负相关（P = 0.015）。
尽管PSA表达与ER的免疫反应性呈负相关，但PSA表达与其他预后因素无关。因此，免疫组化检测PSA似乎不是浸润性乳腺癌患者的重要预后参数。
