红葡萄汁对大鼠阿尔茨海默病的影响。
The effect of red grape juice on Alzheimer's disease in rats.
作者信息
Siahmard Zahra, Alaei Hojjatollah, Reisi Parham, Pilehvarian Ali Asghar
机构信息
Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, India.
出版信息
Adv Biomed Res. 2012;1:63. doi: 10.4103/2277-9175.100188. Epub 2012 Aug 28.
BACKGROUND
Alzheimer's disease is a neurodegenerative disease appearing as a result of free radicals and oxidative stress. Antioxidants agents boost memory and control Alzheimer's disease. Since red grape juice contains antioxidant agents, its effects on speed of learning and improvement of memory was studied in Alzheimer's rats.
MATERIALS AND METHODS
Alzheimer's model was induced by bilateral infusion of streptozocine into lateral ventricles of brain of male rats. Rats drank 10% red grape juice for 21 days. Passive avoidance learning test was used for measuring memory and learning in rats.
RESULTS
Our results showed that learning and memory in STZ-group decreased significantly compared to Sham group. However, intake of red grape juice increased speed of learning and improvement of memory in Alzheimer's rats.
CONCLUSIONS
Our results suggest that there are active ingredients in red grape juice, which probably have therapeutic and preventive effects on cognitive impairments in Alzheimer's disease.
背景
阿尔茨海默病是一种由自由基和氧化应激导致的神经退行性疾病。抗氧化剂可增强记忆力并控制阿尔茨海默病。由于红葡萄汁含有抗氧化剂，因此研究了其对阿尔茨海默病大鼠学习速度和记忆力改善的影响。
材料与方法
通过向雄性大鼠脑侧脑室双侧注射链脲佐菌素诱导阿尔茨海默病模型。大鼠饮用10%的红葡萄汁，持续21天。采用被动回避学习试验来测量大鼠的记忆力和学习能力。
结果
我们的结果表明，与假手术组相比，链脲佐菌素组的学习和记忆能力显著下降。然而，摄入红葡萄汁可提高阿尔茨海默病大鼠的学习速度并改善其记忆力。
结论
我们的结果表明，红葡萄汁中含有活性成分，这些成分可能对阿尔茨海默病的认知障碍具有治疗和预防作用。
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