Pezzuto John M
College of Pharmacy, University of Hawaii at Hilo, 34 Rainbow Drive Hilo, Hawaii 96720, USA.
J Agric Food Chem. 2008 Aug 27;56(16):6777-84. doi: 10.1021/jf800898p. Epub 2008 Jul 29.
Grapes are a valuable source of numerous phytonutrients, including the intensively studied constituent, resveratrol. A question worth addressing is the potential of dietary grape consumption to positively modulate human health. Many studies have suggested cardiovascular benefits, and some work has indicated cancer chemopreventive activity. Data are particularly compelling in the area of skin cancer prevention. With financial support provided by the California Table Grape Commission, novel and exciting preliminary data are emerging from independent research suggesting beneficial activity against other less prevalent but devastating illnesses, such as Alzheimer's disease and urinary bladder dysfunction. It is further suggested that some of the copious amounts of data obtained with resveratrol may be relevant to grape consumption, especially responses that can be mediated by low concentrations of the substance. Whether future specific health claims will be sought from or allowed by regulatory authorities is not known, but based on existing data, it is clear that grapes should be considered an integral component of fruit and vegetable enriched diets that are recommended by health authorities and widely accepted as beneficial for human health and disease prevention.
葡萄是多种植物营养素的宝贵来源，其中包括经过深入研究的成分白藜芦醇。一个值得探讨的问题是，食用葡萄对人体健康是否具有积极的调节作用。许多研究表明，食用葡萄对心血管有益，一些研究还显示出其具有癌症化学预防活性。在皮肤癌预防领域，相关数据尤其令人信服。在加利福尼亚鲜食葡萄委员会的资助下，独立研究得出了新颖且令人兴奋的初步数据，表明葡萄对其他不太常见但极具破坏性的疾病，如阿尔茨海默病和膀胱功能障碍，具有有益作用。进一步的研究表明，一些通过白藜芦醇获得的大量数据可能与食用葡萄有关，尤其是那些可由低浓度该物质介导的反应。目前尚不清楚监管机构未来是否会寻求或允许特定的健康声明，但基于现有数据，很明显葡萄应被视为健康当局推荐的富含水果和蔬菜的饮食中不可或缺的一部分，并且这种饮食被广泛认为对人类健康和疾病预防有益。
