Adibi Atoosa, Mardanian Farahnaz, Hajiahmadi Somaye
Radiology Department, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran.
Adv Biomed Res. 2012;1:71. doi: 10.4103/2277-9175.102975. Epub 2012 Oct 31.
The aim of this study was to determine if the basal antral follicle number and ovarian volume contributes to the prediction of responsiveness in ovulation induction protocol and comparison of it with hormonal tests.
52 irregularly-menstruating patients, aged 18-46 years, participated in this prospective study. All the patients underwent a transvaginal sonography to measure the basal ovarian volume and the basal antral follicles count (AFC). Clomiphene citrate challenge test was measured by summation of measurements of FSH on day 2 and 10. All the women received clomiphene citrate from day 2 to 6. Ovarian responsiveness was measured 1 week after termination of clomiphene citrate and was used as gold standard.
Multiple regression analysis revealed that AFC was the only significant factor for ovarian responsiveness prediction. The area under the curve for AFC to discriminate responder ovaries was 0.66 (95% confidence interval, 0.87-0.99). The cutoff value for predicting ovarian responsiveness was 15.5.
AFC can contribute to the prediction of responsiveness in ovulation induction protocol better than ovarian volume and hormonal tests.
本研究的目的是确定基础窦卵泡数量和卵巢体积是否有助于预测排卵诱导方案中的反应性，并将其与激素检测进行比较。
52名年龄在18至46岁之间月经不规律的患者参与了这项前瞻性研究。所有患者均接受经阴道超声检查以测量基础卵巢体积和基础窦卵泡计数（AFC）。通过第2天和第10天FSH测量值的总和来进行氯米芬激发试验。所有女性从第2天至第6天接受氯米芬治疗。在氯米芬治疗结束1周后测量卵巢反应性，并将其用作金标准。
多元回归分析显示，AFC是预测卵巢反应性的唯一显著因素。AFC区分反应性卵巢的曲线下面积为0.66（95%置信区间，0.87 - 0.99）。预测卵巢反应性的截断值为15.5。
与卵巢体积和激素检测相比，AFC能更好地预测排卵诱导方案中的反应性。
