Department of Biochemistry, Faculty of Medicine, Bulent Ecevit University, Zonguldak, Turkey.
Scand J Clin Lab Invest. 2013 Mar;73(2):135-40. doi: 10.3109/00365513.2012.755739. Epub 2013 Jan 17.
The aim of this study was to determine the normal values of serum IGF-1 and IGFBP-3 in Turkish children and adults (1-79 years).
The study included 571 healthy children and 625 healthy adults from the West Black Sea region of Turkey. Serum IGF-1 and IGFBP-3 concentrations were determined using a chemiluminescent immunometric assay on an Immulite 1000 analyzer.
IGF-1 and IGFBP-3 levels tended to be higher in girls compared to boys among the children. The differences were statistically significant in puberty from age 12-14 years for IGF-1 and prepubertally from age 9-10 years for IGFBP-3. Peaks of serum IGF-1 levels were observed 2 years earlier in girls (14 years) than boys (16 years). The general pattern of IGFBP-3 was similar to IGF-1 during puberty. In adults, IGF-1 and IGFBP-3 levels decreased by age. There was no significant difference in IGF-1 and IGFBP3 values between men and women in any age group.
This study established age- and sex-specific reference values for serum IGF-1 and IGFBP-3 in healthy Turkish children and adults.
本研究旨在确定土耳其儿童和成人（1-79 岁）血清 IGF-1 和 IGFBP-3 的正常值。
该研究纳入了来自土耳其西部黑海岸地区的 571 名健康儿童和 625 名健康成年人。使用 Immulite 1000 分析仪上的化学发光免疫测定法测定血清 IGF-1 和 IGFBP-3 浓度。
在儿童中，女孩的 IGF-1 和 IGFBP-3 水平普遍高于男孩。在青春期（12-14 岁）IGF-1 和青春期前（9-10 岁）IGFBP-3 方面，差异具有统计学意义。女孩的血清 IGF-1 水平峰值比男孩早 2 年（14 岁）。IGFBP-3 的总体模式在青春期与 IGF-1 相似。在成年人中，IGF-1 和 IGFBP-3 水平随年龄增长而降低。在任何年龄组中，男性和女性的 IGF-1 和 IGFBP3 值均无显著差异。
本研究建立了土耳其健康儿童和成人血清 IGF-1 和 IGFBP-3 的年龄和性别特异性参考值。
