Sun Ming, Zhao Yumei, Gu Yi, Zhang Yazhuo
1 Department of Neuropharmacology, Beijing Neurosurgical Institute , Beijing, China .
J Neurotrauma. 2015 Jan 1;32(1):66-74. doi: 10.1089/neu.2012.2432.
Taurine, an abundant amino acid in the nervous system, is reported to reduce ischemic brain injury in a dose-dependent manner. This study was designed to investigate whether taurine protected the brain against closed head injury (CHI) in rats. Taurine was administered intravenously 30 min after CHI. It was found that taurine lessened body-weight loss and improved neurological functions at 7 days after CHI. Moreover, it lowered brain edema and blood-brain barrier permeability, enhanced activity of superoxide dismutase and the level of glutathione, and reduced levels of malondialdehyde and lactic acid in traumatic tissue 24 h after CHI. In addition, it attenuated neuronal cell death in hippocampal CA1 and CA3 subfields 7 days after CHI. All of these effects were dose dependent. These data demonstrated the dose-dependent protection of taurine against experimental CHI and suggest that taurine treatment might be beneficial in reducing trauma-induced oxidative damage to the brain, thus showing the potential for clinical implications.
牛磺酸是神经系统中一种含量丰富的氨基酸，据报道它能以剂量依赖的方式减轻缺血性脑损伤。本研究旨在探讨牛磺酸是否能保护大鼠免受闭合性颅脑损伤（CHI）。在闭合性颅脑损伤后30分钟静脉注射牛磺酸。结果发现，牛磺酸可减轻闭合性颅脑损伤后7天的体重减轻并改善神经功能。此外，它降低了脑水肿和血脑屏障通透性，增强了超氧化物歧化酶的活性和谷胱甘肽水平，并降低了闭合性颅脑损伤后24小时创伤组织中丙二醛和乳酸的水平。此外，它减轻了闭合性颅脑损伤后7天海马CA1和CA3亚区的神经元细胞死亡。所有这些作用均呈剂量依赖性。这些数据证明了牛磺酸对实验性闭合性颅脑损伤的剂量依赖性保护作用，并表明牛磺酸治疗可能有助于减少创伤性脑氧化损伤，从而显示出临床应用潜力。
