Fattahian Hamidreza, Mortazavi Pejman, Moosavian Hamidreza, Mohyeddin Hamid, Moridpour Roozbeh
Department of Surgery, Science and Research Branch, Islamic Azad University, Iran.
J S Afr Vet Assoc. 2012 Aug 7;83(1):18. doi: 10.4102/jsava.v83i1.18.
Accurate diagnostic approaches to differentiate peripheral nerve sheet tumours from others have not been firmly established. The aim of this case report was to diagnose neurofibroma using a combination of diagnostic imaging, histopathology and immunohistochemistry, which were applied to a canine neurofibroma arising in the left mandible. The tumour was surgically excised and examined histologically. Round or spindle cells, with elongated, dense and homogenous chromatin and pale cytoplasm typical of Schwann cells in an abundant fibromyxomatous stroma, with ruby collagen fibres were seen. Immunohistochemistry demonstrated that S-100 and vimentin were more than 70% positive. Neurofibroma may therefore be recognisable using markers such as S-100 and vimentin.
尚未确立将周围神经鞘瘤与其他肿瘤区分开来的准确诊断方法。本病例报告的目的是通过诊断性影像学、组织病理学和免疫组织化学相结合的方法诊断神经纤维瘤，这些方法应用于一只发生于左下颌骨的犬神经纤维瘤。肿瘤经手术切除并进行组织学检查。可见圆形或梭形细胞，其染色质细长、致密且均匀，细胞质淡染，这是雪旺细胞的典型特征，存在于丰富的纤维黏液样基质中，并伴有红宝石样胶原纤维。免疫组织化学显示S - 100和波形蛋白的阳性率超过70%。因此，使用S - 100和波形蛋白等标志物可能有助于识别神经纤维瘤。
