一种用于中药的热塑性弹性体贴片基质：设计与评估。
A thermoplastic elastomer patch matrix for traditional Chinese medicine: design and evaluation.
机构信息
School of Pharmacy, East China University of Science and Technology , Shanghai , China.
出版信息
Drug Dev Ind Pharm. 2014 Feb;40(2):211-21. doi: 10.3109/03639045.2012.755191. Epub 2013 Jan 18.
OBJECTIVE
To design and evaluate a novel pressure sensitive adhesive (PSA) patch containing traditional Chinese medicine (TCM) using styrene-isoprene-styrene (SIS) copolymer.
METHOD
A mixture D-optimal design with ternary response surface diagram was employed in the optimization process. The proportions of SIS copolymer, tackifying resin and plasticizer were selected as the independent variables while tack force, peel strength of the patch and skin penetrability of methyl salicylate were selected as the dependent variables. The optimized patch was then evaluated including in vivo absorption, pharmacological activities and skin irritation, by comparing with a commercial patch based on natural rubber.
RESULTS
The optimized patch, which comprised 30.0% SIS copolymer, 26.6% tackifying resin and 43.4% plasticizer, was superior to commercial patch in skin permeation, pharmacological activities and skin biocompatibility.
CONCLUSION
SIS copolymer was a suitable substitute to natural rubber in producing patches containing TCM formula.
目的
设计并评估一种新型的含中药的压敏胶贴片，使用苯乙烯-异戊二烯-苯乙烯（SIS）共聚物。
方法
采用三元响应面图的 D-最优设计进行优化过程。SIS 共聚物、增粘树脂和增塑剂的比例被选为自变量，而贴片的粘性力、剥离强度和水杨酸甲酯的皮肤渗透性被选为因变量。然后通过与基于天然橡胶的商业贴片进行比较，对优化后的贴片进行体内吸收、药理活性和皮肤刺激性评估。
结果
优化后的贴片，其中 SIS 共聚物占 30.0%，增粘树脂占 26.6%，增塑剂占 43.4%，在皮肤渗透、药理活性和皮肤生物相容性方面优于商业贴片。
结论
SIS 共聚物是一种替代天然橡胶的合适材料，可用于生产含中药配方的贴片。
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