卵巢切除术导致成年 Wistar 大鼠肾脏 Na(+)，K(+)-ATP 酶的过度表达和钠敏感型高血压。
Ovariectomy causes overexpression of renal Na(+),K(+)-ATPase and sodium-sensitive hypertension in adult Wistar rats.
机构信息
Laboratorio de Riñón, Instituto de Investigaciones Médicas A Lanari, Buenos Aires University , Buenos Aires , Argentina.
出版信息
Clin Exp Hypertens. 2013;35(7):475-83. doi: 10.3109/10641963.2012.758273. Epub 2013 Jan 17.
We investigated the effect of ovariectomy(oVx) on renal and systemic hemodynamic, electrolyte excretion and total and dephosphorylated Na(+),K(+)-ATPase α1 subunit (t-d-NKA) in normotensive Wistar rats under a normal sodium (NS, 0.24%) or high sodium (HS, 1%) intake versus intact female (IF). On NS intake, t-d-NKA was higher in oVx rats and overexpressed in the thick ascending limbs (P < .01 vs. IF) and renal plasma flow was increased. On HS intake, oVx rats maintained a greater dephosphorylated NKA, excreted less sodium, and developed arterial hypertension (134 ± 4 vs. IF 112 ± 5 mm Hg, P < .05). Sodium load caused salt-sensitive hypertension in oVx Wistar rats.
我们研究了卵巢切除术（oVx）对正常血压 Wistar 大鼠肾和全身血液动力学、电解质排泄以及总和去磷酸化 Na(+),K(+)-ATP 酶 α1 亚基（t-d-NKA）的影响，这些大鼠在正常钠（NS，0.24%）或高钠（HS，1%）摄入下与完整雌性（IF）相比。在 NS 摄入时，oVx 大鼠的 t-d-NKA 更高，在厚升支中过度表达（P<.01 比 IF），肾血浆流量增加。在 HS 摄入时，oVx 大鼠保持更大的去磷酸化 NKA，排出更少的钠，并发展为动脉高血压（134±4 比 IF 112±5 毫米汞柱，P<.05）。钠负荷引起 oVx Wistar 大鼠的盐敏感型高血压。
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