Department of Pathology, Hospital Universitario 12 de Octubre, Instituto de Investigación i+12, Universidad Complutense, Madrid, Spain.
Semin Diagn Pathol. 2013 Feb;30(1):45-57. doi: 10.1053/j.semdp.2012.01.008.
Benign cutaneous neural neoplasms are one of the most frequent benign mesenchymal tumors in the skin. Because peripheral sheath nerve is composed of different cells, the tumors raised in these structures are varied and usually contain many of these cells. Most of these tumors are easy to diagnose, as usually present characteristic features well-recognized and express -specific immunohistochemical proteins. However, there are so many infrequent variants that many times require distinction from others spindle-cell tumors including melanoma. The tumors differ from one another by displaying a different proportion and arrangement of the various constituents of a peripheral nerve. In this article, we present the most characteristic clinical and histopathological features of many of these frequent benign cutaneous neural tumors including their uncommon variants.
良性皮肤神经肿瘤是皮肤中最常见的良性间叶肿瘤之一。由于周围鞘神经由不同的细胞组成，因此在这些结构中产生的肿瘤是多种多样的，通常包含许多这些细胞。这些肿瘤大多数易于诊断，因为通常具有特征性的公认特征，并表达特异性的免疫组织化学蛋白。然而，存在如此多的罕见变体，以至于许多时候需要将其与其他梭形细胞肿瘤（包括黑色素瘤）区分开来。这些肿瘤通过显示外周神经的各种成分的不同比例和排列而彼此不同。在本文中，我们介绍了许多常见的良性皮肤神经肿瘤的最典型的临床和组织病理学特征，包括其罕见的变体。
