Department of Pathology, Instituto Valenciano de Oncología, Valencia, Spain.
Semin Diagn Pathol. 2013 Feb;30(1):85-94. doi: 10.1053/j.semdp.2012.01.007.
Superficial/cutaneous small round-cell tumors comprise a heterogeneous group of neoplasms including sarcoma, carcinoma, melanoma, and lymphomas. Among superficial sarcomas, the Ewing's sarcoma family of tumors (ESFT) represents a poorly understood rare variant, having a behavioral difference characterized by a relative favorable prognosis. Several problems are still to be resolved in superficial ESFT, including the differential diagnosis between ESFT of bone (intraosseous or periosteal) with superficial infiltration and superficial ESFT with bone infiltration, especially in the fingers. Our aim is to review the most common types of small round-cell tumors included in the differential diagnosis of superficial ESFT, analyzing the histopathology, phenotype, and molecular alterations of each entity.
表浅/皮肤小圆细胞肿瘤包括一组异质性肿瘤，包括肉瘤、癌、黑色素瘤和淋巴瘤。在表浅肉瘤中，尤文氏肉瘤家族肿瘤（ESFT）是一种尚未被充分了解的罕见变体，其行为特征为相对良好的预后。在表浅 ESFT 中仍有几个问题有待解决，包括表浅浸润性骨 ESFT（骨内或骨膜）与骨浸润性表浅 ESFT 的鉴别诊断，尤其是在手指中。我们的目的是回顾表浅 ESFT 鉴别诊断中最常见的小圆细胞肿瘤类型，分析每个实体的组织病理学、表型和分子改变。
