来自锡金大戟的 Jatropholane 型二萜。

Jatropholane-type diterpenes from Euphorbia sikkimensis.

机构信息

Key Laboratory of Economic Plants and Biotechnology, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China.

出版信息

J Nat Prod. 2013 Feb 22;76(2):265-9. doi: 10.1021/np300799n. Epub 2013 Jan 17.

DOI:10.1021/np300799n

PMID:23327832

Abstract

Four new jatropholane-type diterpenes (1-4), named sikkimenoids A-D, were isolated from the aerial parts of Euphorbia sikkimensis. The structural elucidations of 1-4 were accomplished by extensive NMR analyses, and their absolute configurations were established by ECD calculations. Compound 2 exhibited weak antiangiogenic activity with an IC(50) value of 43.0 μM when evaluated using a zebrafish model.

摘要

从锡金大戟（Euphorbia sikkimensis）的地上部分分离得到四个新的吉普烷型二萜（1-4），命名为锡金烯 A-D。通过广泛的 NMR 分析完成了 1-4 的结构阐明，并通过 ECD 计算确定了它们的绝对构型。在斑马鱼模型中评估时，化合物 2 表现出较弱的抗血管生成活性，IC50 值为 43.0 μM。