Hayama Makio, Chida Masayuki, Tamura Motohiko, Kobayashi Satoru, Oyaizu Takeshi, Honma Koichi
Department of General Thoracic Surgery, Dokkyo Medical University, Tochigi, Japan.
Ann Thorac Cardiovasc Surg. 2014;20(4):325-8. doi: 10.5761/atcs.cr.12.01934. Epub 2013 Jan 16.
We report a case with lung cancer during pregnancy, which has a very poor prognosis.A 34-year old female at 30 weeks of pregnancy came to us with a cough and right lower chest pain. Chest computed tomography revealed a mass in the right lower lung lobe and the diagnosis of adenocarcinoma cT2aN1M0 was made. We performed a right sleeve pneumonectomy, as the tumor had progressed to the right main bronchus near carina. Histological sections of the specimens revealed a poorly differentiated adenocarcinoma that infiltrated surrounding structures. The pathological stage of lung cancer was T4N2M0 stage IIIB. Immunohistochemistry findings for estrogen receptor β were positive in the nuclei of the adenocarcinoma. She had a rapid recurrence in spite of chemotherapy, and she died 7.5 months after operation. The positive estrogen receptor and hormonal condition during pregnancy might promote cancer and result in her poor prognosis.
我们报告一例妊娠期肺癌病例，其预后非常差。一名34岁女性，孕30周，因咳嗽和右下胸痛前来就诊。胸部计算机断层扫描显示右下肺叶有一个肿块，诊断为腺癌cT2aN1M0。由于肿瘤已进展至靠近隆突的右主支气管，我们进行了右袖式肺切除术。标本的组织学切片显示为低分化腺癌，浸润周围结构。肺癌的病理分期为T4N2M0 IIIB期。雌激素受体β的免疫组织化学结果显示腺癌细胞核呈阳性。尽管进行了化疗，她仍迅速复发，并在术后7.5个月死亡。妊娠期雌激素受体阳性和激素状态可能促进癌症发展并导致其预后不良。
