Emergency Medicine Department, University of São Paulo, Brazil.
Microbes Infect. 2013 May;15(5):342-6. doi: 10.1016/j.micinf.2013.01.001. Epub 2013 Jan 14.
Host defense peptides are ancient weapons of the innate immunity. The human cathelicidin LL-37 protects the epithelial barrier against infection and is constitutively secreted in the bloodstream by immune cells. Current knowledge claims that LL-37 is up regulated upon infection. LL-37 can protect against bacterial infections and possesses many immunomodulatory properties. Here, we show that the human host defense peptide LL-37 is down regulated during septic shock. Furthermore, we show that these effects are not related to vitamin D serum levels, a potent inducer of LL-37 gene expression, pointing out the complex regulation of cathelicidins during septic shock.
宿主防御肽是先天免疫的古老武器。人类抗菌肽 LL-37 保护上皮屏障免受感染，并由免疫细胞在血液中持续分泌。目前的研究认为，LL-37 在感染时会被上调。LL-37 可以抵抗细菌感染，并具有许多免疫调节特性。在这里，我们发现人类宿主防御肽 LL-37 在感染性休克期间被下调。此外，我们发现这些影响与维生素 D 血清水平无关，维生素 D 是 LL-37 基因表达的有效诱导剂，这表明在感染性休克期间，抗菌肽的调节非常复杂。
