Cornejo Kristine M, Shi Min, Akalin Ali, Uy Karl, Cagle Philip T, Fraire Armando E
Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
J Bronchology Interv Pulmonol. 2013 Jan;20(1):52-7. doi: 10.1097/LBR.0b013e3182814cfd.
Pulmonary papillary adenomas are rare neoplasms that predominantly occur in the periphery of the lung. We describe a 24-year-old male with a 6.0-cm spherical mass found incidentally at the periphery of the left upper lobe by imaging. Enucleation of the neoplasm was performed with intraoperative frozen section analysis. The tumor histologically showed papillary proliferations containing fibrovascular cores lined by a single layer of tumor cells that lacked atypia, mitoses, or necrosis. The histologic features were consistent with a pulmonary papillary adenoma. Pulmonary papillary adenoma was previously considered to be a benign entity. However, because of its invasive growth pattern, it has been suggested that this neoplasm has intermediate malignant potential. The clinicopathologic features and differential diagnosis of this unusual neoplasm is discussed with a review of the English literature.
肺乳头状腺瘤是一种罕见的肿瘤，主要发生在肺周边。我们描述了一名24岁男性，影像学检查偶然发现左肺上叶周边有一个6.0厘米的球形肿块。术中进行了肿瘤摘除并做了冰冻切片分析。肿瘤组织学表现为乳头样增生，有含纤维血管轴心，被单层无异型性、无核分裂象及坏死的肿瘤细胞所覆盖。组织学特征符合肺乳头状腺瘤。肺乳头状腺瘤以前被认为是良性病变。然而，由于其浸润性生长方式，有人提出这种肿瘤具有中间型恶性潜能。本文结合英文文献复习讨论了这种不寻常肿瘤的临床病理特征及鉴别诊断。
