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创建一个具有基因族谱和表型数据链接的国家资源:退伍军人基因族谱项目。

Creation of a national resource with linked genealogy and phenotypic data: the Veterans Genealogy Project.

机构信息

Division of Genetic Epidemiology, Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.

出版信息

Genet Med. 2013 Jul;15(7):541-7. doi: 10.1038/gim.2012.171. Epub 2013 Jan 17.

DOI:10.1038/gim.2012.171
PMID:23328892
Abstract

PURPOSE

Creation of a genealogy of the United States and its ancestral populations is under way. When complete, this US genealogy will be record linked to the National Veteran's Health Administration medical data representing more than 8 million US veterans.

METHODS

Genealogical data are gathered from public sources, primarily the Internet. Record linking using data from relatives is accomplished to integrate multiple data sources and then to link genealogical data to the veteran's demographic data.

RESULTS

This resource currently includes genealogy for more than 22 million individuals representing the Intermountain West and the East Coast. The demographic data for more than 40,000 veteran patients using Veterans Hospital Administration services in Utah and Massachusetts have already been record linked.

CONCLUSION

The resource is only in its second year of creation and already represents the largest such combination of genealogy and medical data in the world. The data sources, the creation of the genealogy, record-linking methods and results, proposed genetic analyses, and future directions are discussed.

摘要

目的

正在创建美国及其祖先群体的谱系。完成后,这个美国谱系将与代表超过 800 万美国退伍军人的国家退伍军人健康管理局医疗数据进行记录链接。

方法

从公共资源(主要是互联网)中收集家谱数据。使用来自亲属的数据进行记录链接,以整合多个数据源,然后将家谱数据链接到退伍军人的人口统计数据。

结果

该资源目前包括超过 2200 万人的家谱,代表了美国内陆西部和东海岸地区。犹他州和马萨诸塞州退伍军人管理局服务中心的 4 万多名退伍军人患者的人口统计数据已经通过记录链接进行了链接。

结论

该资源仅创建了两年,已经是世界上最大的此类家谱和医疗数据的组合。讨论了数据源、家谱的创建、记录链接方法和结果、拟议的遗传分析以及未来的方向。

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Creation of a national resource with linked genealogy and phenotypic data: the Veterans Genealogy Project.创建一个具有基因族谱和表型数据链接的国家资源:退伍军人基因族谱项目。
Genet Med. 2013 Jul;15(7):541-7. doi: 10.1038/gim.2012.171. Epub 2013 Jan 17.
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[Genetic aspects of genealogy].[家谱的遗传学方面]
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Evidence for an Inherited Contribution to Sepsis Susceptibility Among a Cohort of U.S. Veterans.美国退伍军人队列中脓毒症易感性存在遗传因素的证据。
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