Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.
J Perinatol. 2013 Jul;33(7):543-7. doi: 10.1038/jp.2012.170. Epub 2013 Jan 17.
To assess health-care utilization and risk of respiratory morbidities in preterm infants with bronchopulmonary dysplasia (BPD) and pulmonary hypertension (PH).
Retrospective data were obtained from subjects (n=109) attending a BPD clinic. Subjects were stratified by the presence or absence of PH before and after 2 months of age. Analytic methods included t-tests, χ(2) tests and regression.
Subjects with BPD and PH present after 2 months of age were hospitalized for 2.2 months longer than those without PH (P=0.02). These subjects were 4.5 times more likely to receive home supplemental oxygen or mechanical ventilation (P=0.03). No difference in the risk of respiratory morbidities after initial hospital discharge was seen with PH.
PH in preterm infants is associated with longer initial hospitalizations and a higher likelihood of requiring home respiratory support. This has implications for counseling families and reducing the medical, psychosocial, and economic burden of BPD and PH.
评估患有支气管肺发育不良(BPD)和肺动脉高压(PH)的早产儿的医疗保健利用情况和呼吸系统疾病风险。
本研究回顾性地收集了参加 BPD 门诊的患者(n=109)的数据。根据患者在 2 月龄前和后是否存在 PH 进行分层。分析方法包括 t 检验、卡方检验和回归分析。
在 2 月龄后出现 PH 的 BPD 患者的住院时间比无 PH 的患者长 2.2 个月(P=0.02)。这些患者接受家庭补充氧气或机械通气的可能性是无 PH 患者的 4.5 倍(P=0.03)。在初次出院后,PH 与呼吸系统疾病风险无差异。
早产儿 PH 与较长的初始住院时间和更有可能需要家庭呼吸支持相关。这对咨询家庭和减轻 BPD 和 PH 的医疗、心理社会和经济负担具有重要意义。