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性染色体偏性基因表达的进化原因和结果。

The evolutionary causes and consequences of sex-biased gene expression.

机构信息

Department of Biology II, University of Munich (LMU), Grosshaderner Strasse 2, 82152 Planegg-Martinsried, Germany.

出版信息

Nat Rev Genet. 2013 Feb;14(2):83-7. doi: 10.1038/nrg3376.

Abstract

Females and males often differ extensively in their physical traits. This sexual dimorphism is largely caused by differences in gene expression. Recent advances in genomics, such as RNA sequencing (RNA-seq), have revealed the nature and extent of sex-biased gene expression in diverse species. Here we highlight new findings regarding the causes of sex-biased expression, including sexual antagonism and incomplete dosage compensation. We also discuss how sex-biased expression can accelerate the evolution of sex-linked genes.

摘要

女性和男性在身体特征上常常存在广泛差异。这种性别二态性在很大程度上是由基因表达的差异引起的。近年来基因组学的进展,如 RNA 测序(RNA-seq),揭示了不同物种中性别偏向基因表达的性质和程度。在这里,我们重点介绍了关于性别偏向表达原因的新发现,包括性拮抗和不完全剂量补偿。我们还讨论了性别偏向表达如何加速性连锁基因的进化。

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