性染色体偏性基因表达的进化原因和结果。
The evolutionary causes and consequences of sex-biased gene expression.
机构信息
Department of Biology II, University of Munich (LMU), Grosshaderner Strasse 2, 82152 Planegg-Martinsried, Germany.
出版信息
Nat Rev Genet. 2013 Feb;14(2):83-7. doi: 10.1038/nrg3376.
Females and males often differ extensively in their physical traits. This sexual dimorphism is largely caused by differences in gene expression. Recent advances in genomics, such as RNA sequencing (RNA-seq), have revealed the nature and extent of sex-biased gene expression in diverse species. Here we highlight new findings regarding the causes of sex-biased expression, including sexual antagonism and incomplete dosage compensation. We also discuss how sex-biased expression can accelerate the evolution of sex-linked genes.
女性和男性在身体特征上常常存在广泛差异。这种性别二态性在很大程度上是由基因表达的差异引起的。近年来基因组学的进展，如 RNA 测序（RNA-seq），揭示了不同物种中性别偏向基因表达的性质和程度。在这里，我们重点介绍了关于性别偏向表达原因的新发现，包括性拮抗和不完全剂量补偿。我们还讨论了性别偏向表达如何加速性连锁基因的进化。
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