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神经内分泌小肠肿瘤的当前知识状态:基于一例病例的文献非系统性综述

Current state of knowledge on neuroendocrine small bowel tumours: non-systematic review of the literature based on one case.

作者信息

Simion Nicolae Irinel, Muntean Valentin, Fabian Ovidiu

机构信息

CHUV University Medical Center, Emergency Department, Lausanne, Switzerland.

出版信息

BMJ Case Rep. 2013 Jan 17;2013:bcr2012007217. doi: 10.1136/bcr-2012-007217.

DOI:10.1136/bcr-2012-007217
PMID:23329706
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3604276/
Abstract

More than 60% of neuroendocrine tumours, also called carcinoids, are localised within the gastrointestinal tract. Small bowel neuroendocrine tumours have been diagnosed with increasing frequency over the past 35 years, being the second most frequent tumours of the small intestine. Ileal neuroendocrine tumours diagnosis is late because patients have non-specific symptoms. We have proposed to illustrate as an example the case of a patient, and on its basis, to make a brief review of the literature on small bowel neuroendocrine tumours, resuming several recent changes in the field, concerning classification criteria of these tumours and new recommendations and current advances in diagnosis and treatment. This patient came to our emergency department with a complete bowel obstruction, along with a 2-year history of peristaltic abdominal pain, vomits and diarrhoea episodes. During emergency laparotomy, an ileal stricture was observed, that showed to be a neuroendocrine tumour of the small bowel.

摘要

超过60%的神经内分泌肿瘤,也称为类癌,位于胃肠道内。在过去35年中,小肠神经内分泌肿瘤的诊断频率不断增加,是小肠第二常见的肿瘤。回肠神经内分泌肿瘤诊断较晚,因为患者症状不具特异性。我们提议举例说明一名患者的病例,并在此基础上对小肠神经内分泌肿瘤的文献进行简要综述,总结该领域最近的一些变化,包括这些肿瘤的分类标准、新建议以及诊断和治疗方面的当前进展。该患者因完全性肠梗阻来到我们的急诊科,伴有2年的腹部蠕动性疼痛、呕吐和腹泻病史。在急诊剖腹手术中,观察到一段回肠狭窄,结果显示是小肠神经内分泌肿瘤。

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Classification and pathology of gastroenteropancreatic neuroendocrine neoplasms.胃肠胰神经内分泌肿瘤的分类和病理学。
Endocr Relat Cancer. 2011 Oct 17;18 Suppl 1:S1-16. doi: 10.1530/ERC-11-0013. Print 2011 Oct.
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Neuroendocrine tumors: recent progress in diagnosis and treatment.神经内分泌肿瘤:诊断与治疗的最新进展
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Choice of tumour markers in patients with neuroendocrine tumours is dependent on the histological grade. A marker study of Chromogranin A, Neuron specific enolase, Progastrin-releasing peptide and cytokeratin fragments.神经内分泌肿瘤患者的肿瘤标志物选择取决于组织学分级。嗜铬粒蛋白 A、神经元特异性烯醇化酶、胃泌素释放肽和细胞角蛋白片段的标志物研究。
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