毛细胞白血病中的α-L-岩藻糖苷酶同工酶模式

Alpha-L-fucosidase isoenzyme pattern in hairy cell leukaemia.

作者信息

Roger L, Alliot T, Arock M, Bernard M A, Percheron F, Foglietti M J

机构信息

Laboratoire de Chimie Biologique, Faculté des Sciences Pharmaceutiques et Biologiques, Université René Descartes, France.

出版信息

Leuk Res. 1990;14(4):333-5. doi: 10.1016/0145-2126(90)90160-b.

DOI:10.1016/0145-2126(90)90160-b

PMID:2332987

Abstract

alpha-L-Fucosidase isoenzymes pattern in hairy cell leukaemia (HCL) is characterized by the disappearance of the more acidic form when compared to normal lymphocytes. Our data seem to indicate that this profile could not be related to the T or B phenotype because in normal lymphocytes (mainly T), MO cells possessing T markers, as well as lymphocytes from chronic lymphoid leukaemia (CLL) known to exhibit normal-like B phenotypes two alpha-L-fucosidase forms are identified and especially the more acidic one.

摘要

毛细胞白血病（HCL）中的α-L-岩藻糖苷酶同工酶模式的特征是，与正常淋巴细胞相比，酸性更强的形式消失。我们的数据似乎表明，这种情况与T或B表型无关，因为在正常淋巴细胞（主要是T细胞）、具有T标记的MO细胞以及已知表现出正常样B表型的慢性淋巴细胞白血病（CLL）的淋巴细胞中，可鉴定出两种α-L-岩藻糖苷酶形式，尤其是酸性更强的那种。