慢性淋巴细胞白血病中的1-磷酸半乳糖尿苷酰转移酶活性
Galactose-1-phosphate uridylyltransferase activity in chronic lymphocytic leukemia.
作者信息
Johnson L D
出版信息
Cancer Biochem Biophys. 1979;3(2):75-9.
PMID:233300
Abstract
Galactose-1-phosphate uridylytransferase (E.C.2.7.12) activity was measured in both lymphoid and erythroid cells from patients with chronic lymphocytic leukemia (CLL). Decreased enzyme activity was found in both cell types using two assay methods. The results suggest the presence of an inhibitor of the enzyme in CLL patients. A correlation between decreased uridyl transferase activity and glycogen accumulation in CLL is postulated.
摘要
在慢性淋巴细胞白血病（CLL）患者的淋巴细胞和红细胞中均检测了1-磷酸半乳糖尿苷酰转移酶（E.C.2.7.12）的活性。使用两种检测方法均发现这两种细胞类型中的酶活性降低。结果表明CLL患者体内存在该酶的一种抑制剂。推测CLL中尿苷酰转移酶活性降低与糖原积累之间存在相关性。
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