扁平苔藓颊黏膜上皮增殖活性的病理形态学及免疫组化分析
Pathomorphological and immunohistochemical analysis of proliferative activity of the buccal mucosal epithelium in lichen planus.
作者信息
Timoshin S S, Fleishman M Yu, Zagorodnyaya E B, Oskol'skii G I, Zagorodnii A S, Lushnikova E L, Nepomnyashchikh L M
机构信息
Far-Eastern State Medical University, the Ministry of Health and Social Development of the Russian Federation, Khabarovsk, Russia.
出版信息
Bull Exp Biol Med. 2012 Dec;154(2):283-6. doi: 10.1007/s10517-012-1931-1.
Structural reorganization of the buccal mucosa and changes in proliferative activity of epitheliocytes in typical and erosive ulcerative lichen planus were studied. The most manifest diagnostically significant pathomorphological signs of lichen planus of the buccal mucosa are described: acanthosis, granulosis, parakeratosis, lymphocytic infiltration of the lamina propria, and edema. The most pronounced morphological changes and higher index of epitheliocyte proliferative activity (by expression of Ki-67) are characteristic of the erosive ulcerative form of the disease.
研究了典型型和糜烂溃疡性扁平苔藓患者颊黏膜的结构重组以及上皮细胞增殖活性的变化。描述了颊黏膜扁平苔藓最明显且具有诊断意义的病理形态学特征：棘层肥厚、颗粒形成、不全角化、固有层淋巴细胞浸润和水肿。疾病的糜烂溃疡性形式具有最显著的形态学变化和更高的上皮细胞增殖活性指数（通过Ki-67表达）。
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