Verhagen Elise A, Kooi Elisabeth M W, van den Berg Paul P, Bos Arend F
Division of Neonatology, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
J Matern Fetal Neonatal Med. 2013 Jun;26(9):871-6. doi: 10.3109/14767058.2013.766695. Epub 2013 Feb 6.
To determine whether maternal antihypertensive drugs influenced cerebral oxygenation in preterm infants during the first days after birth.
We included 49 preterm infants (median gestational age 30.3 weeks, (range 26.0-31.9), birth weight 1250 g (560-2250)). Regional cerebral oxygen saturation (rcSO2) was measured by near-infrared spectroscopy on postnatal days 1, 2, 3, 4 and 5. Fractional tissue oxygen extraction (FTOE) was calculated using rcSO2 and arterial oxygen saturation (SpO2) values:(SpO2 - rcSO2)/SpO2.
Nine mothers were treated with labetalol and/or MgSO4 during pregnancy, three mothers with labetalol, MgSO4 and nifedipine, and 19 mothers with nifedipine only. Eighteen infants served as controls. Multivariate linear regression analysis showed that exposure to labetalol and/or MgSO4 during pregnancy decreased FTOE on day 1 after birth, while nifedipine did not.
Treating pregnant women with labetalol and/or MgSO4 may influence cerebral oxygen extraction in their offspring shortly after birth.
确定母亲使用的降压药物是否会影响早产儿出生后最初几天的脑氧合情况。
我们纳入了49例早产儿（中位胎龄30.3周，范围26.0 - 31.9周），出生体重1250克（560 - 2250克）。在出生后第1、2、3、4和5天，通过近红外光谱法测量局部脑氧饱和度（rcSO2）。使用rcSO2和动脉血氧饱和度（SpO2）值计算组织氧提取分数（FTOE）：(SpO2 - rcSO2)/SpO2。
9名母亲在孕期接受了拉贝洛尔和/或硫酸镁治疗，3名母亲接受了拉贝洛尔、硫酸镁和硝苯地平治疗，19名母亲仅接受了硝苯地平治疗。18名婴儿作为对照。多变量线性回归分析显示，孕期暴露于拉贝洛尔和/或硫酸镁会降低出生后第1天的FTOE，而硝苯地平则不会。
孕期使用拉贝洛尔和/或硫酸镁治疗可能会影响其后代出生后不久的脑氧提取情况。
