Christou Elizabeth M, Chen Andrew Chih-Chieh, Sugo Ella, Barbaric Draga, Wargon Orli
Sydney Children's Hospital.
Australas J Dermatol. 2014 May;55(2):e24-8. doi: 10.1111/ajd.12017. Epub 2013 Jan 18.
Proliferative nodules (PN) are benign lesions that arise in large congenital melanocytic naevi (LCMN). Clinically and histologically they can be difficult to differentiate from malignancies, which are also associated with LCMN. The PN in this case consisted of undifferentiated spindle cells and exhibited unusual histological features including negative stains for melanocytic markers (S100, HMB45 and MelA), negative stain for c-Kit, high mitotic index and unusual morphology of the lesional cells. As a result, a firm histological classification could not be made, which posed a challenge for the clinical management.
增殖性结节（PN）是发生于巨大先天性黑素细胞痣（LCMN）的良性病变。在临床和组织学上，它们可能难以与同样与LCMN相关的恶性肿瘤相鉴别。该病例中的PN由未分化的梭形细胞组成，并表现出不寻常的组织学特征，包括黑素细胞标志物（S100、HMB45和MelA）染色阴性、c-Kit染色阴性、高有丝分裂指数以及病变细胞的异常形态。因此，无法做出确切的组织学分类，这给临床管理带来了挑战。
