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茶儿茶素与血浆蛋白相互作用的研究进展:结构-亲和力关系、对抗氧化活性的影响及分子对接方面。

Advances on the interaction between tea catechins and plasma proteins: structure-affinity relationship, influence on antioxidant activity, and molecular docking aspects.

机构信息

Department of Chemistry, Central South University, Changsha, PR China.

出版信息

Curr Drug Metab. 2013 May;14(4):446-50. doi: 10.2174/1389200211314040007.

Abstract

Tea materials are widely consumed beverages in the world and are a rich source of dietary polyphenols. Catechins found in tea show excellent antioxidant potential, which is beneficial for many diseases such as cancers and cardiovascular diseases. These Tea catechins can interact with plasma proteins to form soluble or insoluble complexes, which are responsible for their bioactivities in vivo. However, there is little review published recently which focused on tea catechins-plasma protein interaction (TcPI), despite numerous articles have appeared in this field. This review summarizes the recent trend in TcPI studies focusing on metabolism, structure-affinity relationship, influence on antioxidant activity, and molecular docking aspects.

摘要

茶是世界范围内广泛饮用的饮品,也是膳食多酚的丰富来源。茶中发现的儿茶素具有优异的抗氧化潜力,对癌症和心血管疾病等多种疾病有益。这些茶儿茶素可以与血浆蛋白相互作用,形成可溶性或不溶性复合物,这是它们在体内发挥生物活性的原因。然而,尽管该领域已有大量文章发表,但最近很少有综述关注茶儿茶素-血浆蛋白相互作用(TcPI)。本综述总结了 TcPI 研究的最新趋势,重点关注代谢、结构-亲和力关系、对抗氧化活性的影响和分子对接方面。

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