Hilz M J, Huk W, Schellmann B, Sörgel F, Druschky K F
Department of Neurology, University of Erlangen-Nürnberg, Federal Republic of Germany.
Neuroradiology. 1990;32(1):70-3. doi: 10.1007/BF00593948.
A case of inadvertent intrathecal injection of diatrizoate meglumine is presented. After myelography with 10 ml i.e. 6.5 g Angiografin, a 76-year-old man rapidly developed myoclonus, drowsiness and excessive metabolic acidosis. He died only a few hours later. Postmortem showed non-specific brain edema. RP-HPL-Chromatography confirmed high concentration of the contrast medium in CSF (6 mg/ml) which must have induced refractory central nervous dysregulation. The lethal effects of the misapplication of this agent on the nervous system are discussed.
本文报告一例无意中鞘内注射泛影葡胺的病例。一名76岁男性在接受10毫升（即6.5克泛影葡胺）脊髓造影后，迅速出现肌阵挛、嗜睡和严重代谢性酸中毒。数小时后死亡。尸检显示非特异性脑水肿。反相高效液相色谱法证实脑脊液中造影剂浓度很高（6毫克/毫升），这必定引发了难治性中枢神经调节紊乱。文中讨论了该药物误用对神经系统的致死作用。
