Mcm10 在 DNA 复制中的神秘角色。
Enigmatic roles of Mcm10 in DNA replication.
机构信息
Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
出版信息
Trends Biochem Sci. 2013 Apr;38(4):184-94. doi: 10.1016/j.tibs.2012.12.003. Epub 2013 Jan 17.
Abstract
Minichromosome maintenance protein 10 (Mcm10) is required for DNA replication in all eukaryotes. Although the exact contribution of Mcm10 to genome replication remains heavily debated, early reports suggested that it promotes DNA unwinding and origin firing. These ideas have been solidified by recent studies that propose a role for Mcm10 in helicase activation. Whereas the molecular underpinnings of this activation step have yet to be revealed, structural data on Mcm10 provide further insight into a possible mechanism of action. The essential role in DNA replication initiation is not mutually exclusive with additional functions that Mcm10 may have as part of the elongation machinery. Here, we review the recent findings regarding the role of Mcm10 in DNA replication and discuss existing controversies.
摘要
微染色体维持蛋白 10（Mcm10）是所有真核生物进行 DNA 复制所必需的。尽管 Mcm10 对基因组复制的确切贡献仍存在很大争议，但早期的报告表明，它能促进 DNA 解旋和起始点的引发。最近的研究进一步证实了 Mcm10 在解旋酶激活中的作用，这些研究使这些观点得到了巩固。尽管该激活步骤的分子基础尚未被揭示，但 Mcm10 的结构数据为其可能的作用机制提供了进一步的见解。Mcm10 在 DNA 复制起始中的关键作用并不排斥其作为延伸机制的一部分所具有的其他功能。在这里，我们回顾了关于 Mcm10 在 DNA 复制中的作用的最新发现，并讨论了现有的争议。
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