Department for Interventions in Healthcare Facilities, Hellenic Centre for Disease Control and Prevention, Athens, Greece.
J Hosp Infect. 2013 Mar;83(3):185-92. doi: 10.1016/j.jhin.2012.10.013. Epub 2013 Jan 16.
Viral haemorrhagic fevers (VHFs) typically manifest as rapidly progressing acute febrile syndromes with profound haemorrhagic manifestations and very high fatality rates. VHFs that have the potential for human-to-human transmission and onset of large nosocomial outbreaks include Crimean-Congo haemorrhagic fever, Ebola haemorrhagic fever, Marburg haemorrhagic fever and Lassa fever. Nosocomial outbreaks of VHFs are increasingly reported nowadays, which likely reflects the dynamics of emergence of VHFs. Such outbreaks are associated with an enormous impact in terms of human lives and costs for the management of cases, contact tracing and containment. Surveillance, diagnostic capacity, infection control and the overall preparedness level for management of a hospital-based VHF event are very limited in most endemic countries. Diagnostic capacities for VHFs should increase in the field and become affordable. Availability of appropriate protective equipment and education of healthcare workers about safe clinical practices and infection control is the mainstay for the prevention of nosocomial spread of VHFs.
病毒性出血热(VHF)通常表现为迅速进展的急性发热综合征,伴有严重的出血表现和极高的病死率。具有人际传播潜力和引发大规模医院感染暴发的 VHF 包括克里米亚-刚果出血热、埃博拉出血热、马尔堡出血热和拉萨热。如今,越来越多的医院感染暴发病毒性出血热,这可能反映了病毒性出血热的出现动态。此类暴发对人类生命和病例管理、接触者追踪和控制的成本造成了巨大影响。在大多数地方性流行国家,医院感染暴发病毒性出血热的监测、诊断能力、感染控制和整体管理准备水平非常有限。病毒性出血热的诊断能力应在现场得到提高,并降低成本。提供适当的防护设备和对医护人员进行安全临床实践和感染控制方面的教育,是预防医院感染病毒性出血热传播的主要措施。