原发性甲状旁腺功能亢进症胃酸分泌的进一步研究。
The further investigation on the gastric acid secretion in the primary hyperparathyroidism.
作者信息
Segawa K, Nakazawa S, Naito Y, Imai K, Yamase H, Yamada K, Yamamoto T, Ichikawa M, Hidano H, Kachi T, Hayashi S, Kawaguchi S, Tsukamoto Y, Kajikawa M, Kimoto E, Ichikawa T
出版信息
Gastroenterol Jpn. 1977;12(5):347-51. doi: 10.1007/BF02774530.
The gastric acid output was studied in the 11 patients of hyperparathyroidism before and after parathyroidectomy. The gastric acid output before operation was almost equal to the normal control in our hospital. After the correction of serum calcium by parathyroidectomy, the gastric acid output and serum gastrin were decreased. The decreased gastric acid output was recovered as the days passed since operation and approached to the preoperative level. The acid output in hyperparathyroidism was less in the case whose activity of alkaline phosphatase was more, which suggested that the calcium deposition on gastric mucosa might damage the parietal cell as the result of long lasting hypercalcemia.
对11例甲状旁腺功能亢进患者在甲状旁腺切除术前和术后的胃酸分泌情况进行了研究。手术前的胃酸分泌量与我院正常对照组几乎相等。甲状旁腺切除术后血清钙得到纠正，胃酸分泌量和血清胃泌素均下降。随着术后时间的推移，胃酸分泌量下降的情况逐渐恢复，并接近术前水平。甲状旁腺功能亢进患者中，碱性磷酸酶活性越高，胃酸分泌量越低，这表明长期高钙血症导致胃黏膜钙沉积可能会损伤壁细胞。
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