Waterman A E, Kalthum W
Department of Veterinary Surgery, University of Bristol, Langford.
Res Vet Sci. 1990 Mar;48(2):245-8.
The pharmacokinetics of pethidine administered postoperatively both intravenously and intramuscularly was investigated in dogs aged over 10 years. When the drug was given intravenously (2 mg kg-1), plasma levels declined in a biexponential manner, with an elimination half-life of 62.7 minutes. Following its intramuscular administration at the same dose rate, absorption was very slow and two distinct rates of absorption were observed. Maximum plasma concentrations were not achieved until 33 minutes after drug administration. The elimination of the intramuscularly administered drug was also slow with a t 1/2 beta' of 145.9 minutes. Thus, it seems that in elderly animals pethidine has a long elimination half-life and a slowed rate of absorption. However, the total body clearance of the drug does not seem to be affected by age.
对10岁以上的犬类术后静脉注射和肌肉注射哌替啶的药代动力学进行了研究。当静脉注射该药物（2毫克/千克）时，血浆浓度呈双指数下降，消除半衰期为62.7分钟。以相同剂量率肌肉注射后，吸收非常缓慢，观察到两种不同的吸收速率。给药后33分钟才达到最大血浆浓度。肌肉注射药物的消除也很缓慢，β'半衰期为145.9分钟。因此，在老年动物中，哌替啶似乎具有较长的消除半衰期和较慢的吸收速率。然而，该药物的总体清除率似乎不受年龄影响。
