唑来膦酸增强人食管鳞癌细胞放射敏感性及其潜在机制。
The enhancement of radiosensitivity in human esophageal squamous cell carcinoma cells by zoledronic acid and its potential mechanism.
机构信息
Department of Pharmacy, Luohe Medical College, 148 Daxue-Road, Luohe, 462002, China,
出版信息
Cytotechnology. 2014 Jan;66(1):17-25. doi: 10.1007/s10616-012-9532-4. Epub 2013 Jan 19.
Abstract
Esophageal squamous cell carcinoma (ESCC) has a low 5-year patient survival rate. Radiotherapy, as a preoperative or postoperative treatment of surgery, has a crucial role in improving local control and survival of ESCC. Various chemotherapeutic and biologic agents have been used as radio-sensitizers in combination with radiotherapy. Here, we demonstrate that zoledronic acid (ZOL) has a radio-sensitizing effect on ESCC cells. Exposure of ESCC cancer cells to ZOL plus radiation resulted in increased cell death through arresting the cell cycle between S and G2/M phases. ZOL appeared to inhibit proliferation, tube formation and invasion of endothelial cells. These anti-angiogenetic effects were more marked concurrently with irradiation. In addition, synergistic suppressive effects on VEGF expression were observed after combined treatment. Our data suggest that the combination of ZOL and radiation is a promising therapeutic strategy to enhance radiation therapy for ESCC patients.
摘要
食管鳞状细胞癌（ESCC）患者的 5 年生存率较低。放疗作为手术的术前或术后治疗，对于改善 ESCC 的局部控制和生存至关重要。各种化疗药物和生物制剂已被用作放射增敏剂与放疗联合使用。在这里，我们证明唑来膦酸（zoledronic acid，ZOL）对 ESCC 细胞具有放射增敏作用。ZOL 联合辐射暴露于 ESCC 癌细胞可通过将细胞周期阻滞在 S 和 G2/M 期之间来增加细胞死亡。ZOL 似乎抑制了增殖、管形成和内皮细胞侵袭。这些抗血管生成作用在照射时更为明显。此外，联合治疗后观察到对 VEGF 表达的协同抑制作用。我们的数据表明，ZOL 和辐射的联合治疗是增强 ESCC 患者放射治疗的一种很有前途的治疗策略。
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