Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Arthritis Care Res (Hoboken). 2013 Jul;65(7):1183-9. doi: 10.1002/acr.21940.
Loss of participants in longitudinal data collection can affect the validity of outcomes in rheumatoid arthritis (RA) registries. Prior research indicates that demographics and socioeconomic and psychosocial factors contribute to attrition. This study analyzed the characteristics of an RA registry that may contribute to attrition in a hospital-based population.
Subjects consisted of RA patients enrolled in the Brigham and Women's Rheumatoid Arthritis Sequential Study. Demographics and clinical and psychological factors were evaluated in univariate analyses to determine differences between participants who dropped out and those who completed 5 years of followup. Univariate factors with a P value <0.1 were used in a survival analysis to determine significant factors associated with attrition. A secondary analysis looked at patients who dropped out during the first year.
A total of 1,144 RA participants were enrolled (509 completed 5 years of followup, 227 were still actively enrolled, and 408 dropped out). The attrition rate was 4.31% per 6-month cycle. Shorter disease duration, higher disease activity (3-variable Disease Activity Score in 28 joints using the C-reactive protein level), less education, RA drug therapy, and lower arthritis self-efficacy were statistically significant in multivariate survival analyses. In a secondary analysis, sex and age were the only additional factors found that contributed to attrition.
The attrition rate for this registry was similar to rates reported by other registries. Shorter disease duration, higher disease activity, and several other socioeconomic factors were associated. Men and younger patients tended to drop out during the first year. Population differences in each registry may result in different attrition patterns and ultimately, each longitudinal registry should consider conducting its own analyses.
在纵向数据收集过程中，参与者的流失可能会影响类风湿关节炎（RA）登记处的结果有效性。先前的研究表明，人口统计学、社会经济和心理社会因素会导致数据流失。本研究分析了一个 RA 登记处的特征，这些特征可能会导致基于医院人群的数据流失。
研究对象为参加布莱根妇女医院类风湿关节炎连续研究的 RA 患者。在单变量分析中评估了人口统计学、临床和心理因素，以确定退出者和完成 5 年随访者之间的差异。使用单变量因素 P 值<0.1 进行生存分析，以确定与数据流失相关的显著因素。二次分析着眼于第一年退出的患者。
共纳入 1144 例 RA 患者（509 例完成 5 年随访，227 例仍在积极入组，408 例退出）。每 6 个月周期的流失率为 4.31%。疾病持续时间较短、疾病活动度较高（使用 C 反应蛋白水平的 28 个关节 3 变量疾病活动评分）、教育程度较低、RA 药物治疗和关节炎自我效能较低在多变量生存分析中具有统计学意义。在二次分析中，性别和年龄是唯一发现的与流失相关的其他因素。
该登记处的流失率与其他登记处报告的率相似。较短的疾病持续时间、较高的疾病活动度和其他几个社会经济因素与数据流失有关。男性和年轻患者在第一年更倾向于退出。每个登记处的人群差异可能导致不同的流失模式，最终每个纵向登记处都应考虑进行自己的分析。
