B 细胞和抗体在移植中的矛盾功能。
The paradoxical functions of B cells and antibodies in transplantation.
机构信息
Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
出版信息
J Immunol. 2013 Feb 1;190(3):875-9. doi: 10.4049/jimmunol.1100120.
Abstract
Scarcely anyone would dispute that donor-specific B cells and the Abs that they produce can cause rejection of transplants. Less clear and more controversial, however, is the possibility that donor-specific B cells and the Abs that they produce are one or more means by which transplants can be protected from injury. In this article, we review and discuss this possibility and consider how less well-known functions of B cells and Abs might impact on the design of therapeutics and the management of transplant recipients.
摘要
几乎没有人会质疑供体特异性 B 细胞及其产生的抗体可导致移植物排斥。然而，不太明确且更具争议的是，供体特异性 B 细胞及其产生的抗体是否是保护移植物免受损伤的一种或多种手段。在本文中，我们回顾并讨论了这种可能性，并探讨了 B 细胞和抗体的不太为人知的功能如何影响治疗的设计和移植受者的管理。
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