Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan, United States.
ACS Chem Neurosci. 2013 Jan 16;4(1):22-5. doi: 10.1021/cn300224n.
The dorsal raphe nucleus contains one of the largest groups of serotonergic neurons in the mammalian brain and is the main site of origin of the serotonergic projection to the cerebral cortex. Early electrophysiological studies suggested that serotonergic neurons in this cell group formed a homogeneous cell class. More recent studies however have reported heterogeneity among the core anatomical and electrophysiological properties of these neurons, thus raising the possibility that serotonergic neurons of this cell group may form two or more distinct cell classes. In this Viewpoint, we review these findings and suggest ways to look at cellular heterogeneity among serotonergic neurons.
中缝背核包含哺乳动物大脑中最大的 5-羟色胺能神经元群之一，是 5-羟色胺能投射到大脑皮层的主要起源部位。早期电生理学研究表明，该细胞群中的 5-羟色胺能神经元构成了一个同质的细胞群。然而，最近的研究报告称，这些神经元的核心解剖和电生理特性存在异质性，因此，该细胞群中的 5-羟色胺能神经元可能形成两个或更多不同的细胞群。在本观点中，我们回顾了这些发现，并提出了观察 5-羟色胺能神经元细胞异质性的方法。
