Zhuang Ling, Zhang Yong-jie, Tang Zhen, Dong Chen, Zhou Lu, Qian Hui-min, Tang Fen-yang, Zhen Shi-qi
Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2012 Dec;33(12):1269-72.
To explore the distribution of prevalence rates of typhoid and paratyphoid, with drug resistance and molecular types of Salmonella (S.) typhi and S. paratyphi in Jiangsu province.
Data, collected by the national infectious disease reporting system in Jiangsu province from 2007 to 2011, was analyzed. K-B method was used to test the sensibility to 9 kinds of antibiotics among 210 stains of S. typhi and S. paratyphi. 81 strains of S. typhi were classified by pulse-field gel electrophoresis (PFGE).
The annual average incidence of typhoid and paratyphoid was 0.47 per 100 000 in the last five years, showing a decreasing trend. Highest incidence (1.70 per 100 000) was seen in the < 1 year age group, with S. typhi and S. paratyphi A accounted for 66.19% and 23.81% among the 210 stains. The rate of drug resistance to nalidixic acid appeared to be the highest as 66.19%. The drug resistant rates to 6 kinds of antibiotics were on average, lower than 10.00%. The multi-drug resistant rate of S. typhi and S. paratyphi was 30.00%. In the last 3 years, 37 types from 81 S. typhi strains had been classified into 4 clusters by PFGE. The predominant type was JPPX01. JS0027, accounted for 11.11%. JPPX01.JS0001 type had a specific regional distribution, but JPPX01.JS0014, JPPX01.JS0018 and JPPX01.JS0024 strains were widely spread. Results from the clustering analysis showed that cases in the 3 events tended to have a clustering nature.
The morbidity of typhoid and paratyphoid was in a relatively low level in Jiangsu province. Although S. typhi and S. paratyphi were sensitive to most of the commonly used antibiotics, the resistance rates to some kinds of antibiotics were increasing. The distribution of typhoid was sporadic in Jiangsu and without the dominant strain, it was unlikely that typhoid could become epidemic in the future, in Jiangsu.
探讨江苏省伤寒和副伤寒的患病率分布、耐药情况以及伤寒沙门菌和副伤寒沙门菌的分子分型。
分析江苏省国家传染病报告系统2007年至2011年收集的数据。采用K-B法检测210株伤寒沙门菌和副伤寒沙门菌对9种抗生素的敏感性。对81株伤寒沙门菌进行脉冲场凝胶电泳（PFGE）分型。
过去五年伤寒和副伤寒的年平均发病率为十万分之0.47，呈下降趋势。<1岁年龄组发病率最高（十万分之1.70），在210株菌株中，伤寒沙门菌和甲型副伤寒沙门菌分别占66.19%和23.81%。对萘啶酸的耐药率最高，为66.19%。对6种抗生素的耐药率平均低于10.00%。伤寒沙门菌和副伤寒沙门菌的多重耐药率为30.00%。在过去3年中，81株伤寒沙门菌的37种类型通过PFGE分为4个簇。优势型为JPPX01.JS0027，占11.11%。JPPX01.JS0001型有特定的区域分布，但JPPX01.JS0014、JPPX01.JS0018和JPPX01.JS0024菌株广泛传播。聚类分析结果表明，3起事件中的病例具有聚集性。
江苏省伤寒和副伤寒发病率处于较低水平。虽然伤寒沙门菌和副伤寒沙门菌对大多数常用抗生素敏感，但对某些抗生素的耐药率在上升。伤寒在江苏省呈散发分布，无优势菌株，未来在江苏省不太可能流行。
