Zhang Chan, Shan Ke-ren, He Yan, Wang Chan-juan, Zhang Ting, Li Yi, Deng Jie, Li Lin-jie, Ouyang Kai, Guan Zhi-zhong
Reproductive IVF Center of Luoyang Central Hospital, Luoyang 471002, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2012 Dec;33(12):1279-82.
To investigate the association between both regulated upon activation normal T cell expressed and secreted (RANTES) -403G/A, -28C/G gene polymorphism and the susceptibilities to hepatitis B virus (HBV) infection, among people with Dong and Han ethnicities, in Guizhou.
A total of 229 individuals with HBV persistence infection, 161 HBV clearanced patients and another 200 controls were recruited to conduct a case-control study among residents with Dong or Han ethnicities. Allelic frequencies of both RANTES-403G/A and -28C/G were identified by TaqMan-MGB probe.
Both RANTES-403G/A and -28C/G polymorphism in the HBV-persistent group, when compared to the HBV-clearances group, no significant difference was found (P > 0.05).
from the univariate analysis showed that subjects carrying -403AG and -28GG genotype had higher risk on the susceptibility to HBV persistence infection. The distributions of RANTES-28C/G gene polymorphism between Dong minority and Han ethnicities regarding HBV persistence showed statistically significant difference (P < 0.05). There was no difference on the distributions of RANTES-403G/A gene polymorphism between Dong minority and Han ethnicities.
Patients that carrying both RANTES-403AG and -28GG genotype had higher risk on the persistence to HBV, while RANTES-403A had contributed to the clearance of HBV infection.
探讨贵州侗族和汉族人群中，活化正常T细胞表达和分泌调节因子（RANTES）-403G/A、-28C/G基因多态性与乙型肝炎病毒（HBV）感染易感性之间的关联。
共招募229例HBV持续感染个体、161例HBV清除患者以及另外200名对照，在侗族或汉族居民中开展病例对照研究。采用TaqMan-MGB探针鉴定RANTES-403G/A和-28C/G的等位基因频率。
与HBV清除组相比，HBV持续感染组的RANTES-403G/A和-28C/G多态性均未发现显著差异（P>0.05）。
单因素分析显示，携带-403AG和-28GG基因型的受试者对HBV持续感染的易感性风险更高。侗族和汉族之间关于HBV持续感染的RANTES-28C/G基因多态性分布存在统计学显著差异（P<0.05）。侗族和汉族之间RANTES-403G/A基因多态性分布无差异。
携带RANTES-403AG和-28GG基因型的患者HBV持续感染风险更高，而RANTES-403A有助于清除HBV感染。
