Gundersen B, Gilhus N E, Aarli J A
Nevrologisk avdeling, Haukeland sykehus, Bergen.
Tidsskr Nor Laegeforen. 1990 Apr 10;110(10):1207-8.
The article reviews age, symptoms, diagnosis, response to thymectomy, survival and concomitant disease in 15 patients with myasthenia gravis and thymoma registered in the period 1947-87. The thymomas were locally asymptomatic. The combination of roentgenological investigation and serological detection of nonreceptor muscle antibodies indicated the presence of a thymoma in 13 out of 14 patients. In eight out of nine patients with benign thymomas, myasthenic symptoms improved after thymectomy. Six out of eight patients with noninvasive thymomas survived five years, as opposed to one out of four with invasive thymomas. Associated disorders included polymyositis, myocarditis, parkinsonism and amnesia.
本文回顾了1947年至1987年间登记的15例重症肌无力合并胸腺瘤患者的年龄、症状、诊断、胸腺切除反应、生存率及伴发疾病。胸腺瘤局部无症状。X线检查与非受体肌肉抗体的血清学检测相结合，显示14例患者中有13例存在胸腺瘤。9例良性胸腺瘤患者中有8例在胸腺切除术后肌无力症状改善。8例非侵袭性胸腺瘤患者中有6例存活了5年，而侵袭性胸腺瘤患者中4例只有1例存活。相关疾病包括多发性肌炎、心肌炎、帕金森病和失忆症。
