Singh R K, Jamaluddin M, Ogura H, Takayanagi H
Department of Chemistry, Aligarh Muslim University, India.
Steroids. 1990 Mar;55(3):120-2. doi: 10.1016/0039-128x(90)90007-x.
Reactions of steroidal epoxides such as 5,6 alpha-epoxy-5 alpha-cholestane (I) and its 3 beta-chloro (II) and 3 beta-acetoxy (III) analogs with urea in dimethylformamide afforded 6 beta-amino-5 alpha-cholestan-5-ol (IV-VI), 6 beta-amino-N-formyl-5 alpha-cholestan-5-ol (VII-IX), and 6 beta-amino-N-amido-5 alpha-cholestan-5-ol (X-XII), along with the 5 alpha-cholestane-5,6 beta-diol (XIII-XV). In addition to these compounds, the 3 beta-acetoxy analog also afforded the N-carboxyl derivative (XVI).
甾体环氧化物如5,6α - 环氧 - 5α - 胆甾烷（I）及其3β - 氯代物（II）和3β - 乙酰氧基物（III）在二甲基甲酰胺中与尿素反应，得到6β - 氨基 - 5α - 胆甾烷 - 5 - 醇（IV - VI）、6β - 氨基 - N - 甲酰基 - 5α - 胆甾烷 - 5 - 醇（VII - IX）和6β - 氨基 - N - 酰胺基 - 5α - 胆甾烷 - 5 - 醇（X - XII），以及5α - 胆甾烷 - 5,6β - 二醇（XIII - XV）。除了这些化合物外，3β - 乙酰氧基类似物还生成了N - 羧基衍生物（XVI）。
