Sanhadji K, Negrier M S, Touraine J L
Transplantation and Immunobiology Laboratory, Hôpital Edouard Herriot, Lyon, France.
Thymus. 1990 Feb;15(1):57-64.
Mice with severe combined immunodeficiency (CB 17 scid) received isogeneic and allogeneic fetal liver cell transplantation. Immunological reconstitution was followed by immunoglobulin production, mitogen-induced proliferation, spleen and thymus lymphoid recolonization. Scid mice injected with isogeneic fetal liver cells showed normal IgM, IgG production and subnormal Con-A induced proliferation. Lymphoid organs were gradually repopulated. Mice having received allogeneic stem cells presented normal IgM and IgG secretion. They still had no mitogen-induced lymphocyte stimulation, two months after fetal cell transplantation, despite satisfactory repopulation of spleen and thymus. Reconstitution of cell-mediated immunity may be somewhat slower following allogeneic than isogeneic stem cell transplantation.
患有严重联合免疫缺陷（CB 17 scid）的小鼠接受了同基因和异基因胎儿肝细胞移植。免疫重建后出现免疫球蛋白产生、丝裂原诱导的增殖、脾脏和胸腺淋巴细胞再定植。注射同基因胎儿肝细胞的scid小鼠显示出正常的IgM、IgG产生以及低于正常水平的Con-A诱导增殖。淋巴器官逐渐重新填充。接受异基因干细胞的小鼠表现出正常的IgM和IgG分泌。尽管脾脏和胸腺重新填充情况良好，但在胎儿细胞移植两个月后，它们仍然没有丝裂原诱导的淋巴细胞刺激。异基因干细胞移植后细胞介导免疫的重建可能比同基因干细胞移植稍慢。
